DegronMD

Uniprot ID: Q4VCS5

Source protein: Angiomotin

Source gene: AMOT

Class: DEG_SCF_FBW7_1

Location: 1010:1017

E3 ligase: FBXW7

DEGRON score: 0.915

ASA_SCORE: 93.7875

COIL: 0.9649

CONS_SCORE: 0.2658

DSS_SCORE: 0.645

HELIX: 0.0105

FCONS_SCORE: 1.0019

RIG_SCORE: 0.5742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1002L	TCGA-55-8510	LUAD	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	0.1111
p.Q1002L	DO24339	LUAD	ICGC	VAPTPAPT	DEG_SCF_FBW7_1	0.1111
p.V1010M	TCGA-73-4668	LUAD	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	0.6097
p.A1025D	TCGA-A6-6781	COAD	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	0.1111
p.A1025D	DO8447	COAD	ICGC	VAPTPAPT	DEG_SCF_FBW7_1	0.1111
p.A1007V	TCGA-AX-A0J0	UCEC	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	0.25
p.A1007V	DO41133	UCEC	ICGC	VAPTPAPT	DEG_SCF_FBW7_1	0.25
p.E1026K	TCGA-ZF-A9RL	BLCA	TCGA	VAPTPAPT	DEG_SCF_FBW7_1	0.0833
p.A1007S	SIDM00419	Ewing's Sarcoma	GDSC	VAPTPAPT	DEG_SCF_FBW7_1	0.25
p.A1007S	ACH-000424	Bone Cancer	CCLE	VAPTPAPT	DEG_SCF_FBW7_1	0.25
p.A1007S	TC-71	bone	COSMIC	VAPTPAPT	DEG_SCF_FBW7_1	0.25
p.V1027A	SIDM00490	Glioma	GDSC	VAPTPAPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4VCS5	Angiomotin	DEG_SCF_FBW7_1	1010:1017	VAPTPAPT	FBXW7	0.915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons