DegronMD

Uniprot ID: Q4VCS5

Source protein: Angiomotin

Source gene: AMOT

Class: DEG_SCF_FBW7_1

Location: 845:852

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 86.275

COIL: 0.9556

CONS_SCORE: 0.4649

DSS_SCORE: 0.6732

HELIX: 0.0204

FCONS_SCORE: 1.0453

RIG_SCORE: 0.6282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S842L	TCGA-AJ-A3EK	UCEC	TCGA	PPSTPLLS	DEG_SCF_FBW7_1	0.6944
p.K856R	TCGA-DM-A1D8	COAD	TCGA	PPSTPLLS	DEG_SCF_FBW7_1	0.3333
p.S839F	TCGA-EB-A5FP	SKCM	TCGA	PPSTPLLS	DEG_SCF_FBW7_1	0.1667
p.S852L	DO229027	LICA	ICGC	PPSTPLLS	DEG_SCF_FBW7_1	0.7667
p.L851V	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PPSTPLLS	DEG_SCF_FBW7_1	0.5654
p.L851V	ACH-000589	Lung Cancer	CCLE	PPSTPLLS	DEG_SCF_FBW7_1	0.5654
p.L851V	NCI-H1437	lung	COSMIC	PPSTPLLS	DEG_SCF_FBW7_1	0.5654
p.Q841P	NCI-H661	lung	COSMIC	PPSTPLLS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4VCS5	Angiomotin	DEG_SCF_FBW7_1	845:852	PPSTPLLS	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons