DegronMD - Q5T5X7(BEND3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P244L	TCGA-66-2756	LUSC	TCGA	PPEY	ITCH	243:246	Mutation altering degron motif	0.7582
p.P244L	DO27128	LUSC	ICGC	PPEY	ITCH	243:246	Mutation altering degron motif	0.7582
p.D704Y	TCGA-66-2793	LUSC	TCGA	DELVVPSP	DEG_COP1_1	704:711	Mutation altering degron motif	0.7325
p.D704Y	DO27334	LUSC	ICGC	DELVVPSP	DEG_COP1_1	704:711	Mutation altering degron motif	0.7325
p.L253F	TCGA-86-A4JF	LUAD	TCGA	PPEY	ITCH	243:246	Mutation rewiring degron network	0.1389
p.L253F	DO45317	LUAD	ICGC	PPEY	ITCH	243:246	Mutation rewiring degron network	0.1389
p.G263V	TCGA-A6-6652	COAD	TCGA	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.G263V	DO7946	COAD	ICGC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.V282M	TCGA-B5-A3FC	UCEC	TCGA	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.1944
p.V282M	DO41871	UCEC	ICGC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.1944
p.P714L	TCGA-CA-5256	COAD	TCGA	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.25
p.P714L	DO10526	COAD	ICGC	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.25
p.P702L	TCGA-D6-6516	HNSC	TCGA	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.2778
p.P702L	DO15623	HNSC	ICGC	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.2778
p.P244S	TCGA-FV-A4ZP	LIHC	TCGA	PPEY	ITCH	243:246	Mutation altering degron motif	0.6752
p.P244S	DO44911	LIHC	ICGC	PPEY	ITCH	243:246	Mutation altering degron motif	0.6752
p.R286W	TCGA-HV-AA8V	PAAD	TCGA	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.R286W	DO223713	PAAD	ICGC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.E235K	TCGA-OR-A5L4	ACC	TCGA	PPEY	ITCH	243:246	Mutation rewiring degron network	0.1111
p.D283Y	TCGA-WK-A8XT	SARC	TCGA	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.1667
p.D283Y	DO220298	SARC	ICGC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.1667
p.P718S	TCGA-YD-A9TA	SKCM	TCGA	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.1389
p.P718S	DO219503	SKCM	ICGC	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.1389
p.T249S	DO233819	GACA	ICGC	PPEY	ITCH	243:246	Mutation rewiring degron network	0.25
p.E277K	DO233850	GACA	ICGC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation altering degron motif	0.7022
p.P242Q	DO228971	LICA	ICGC	PPEY	ITCH	243:246	Mutation rewiring degron network	0.3056
p.D283E	DO229035	LICA	ICGC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.1667
p.K239E	DO220872	MELA	ICGC	PPEY	ITCH	243:246	Mutation substituting flanking lysine	0.3333
p.P714S	DO229456	SKCA	ICGC	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.25
p.D712G	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.3056
p.D712G	ACH-002272	Lymphoma	CCLE	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.3056
p.D712G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.3056
p.G287V	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0556
p.G287V	ACH-000015	Lung Cancer	CCLE	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0556
p.G287V	NCI-H1581	lung	COSMIC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0556
p.D704V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DELVVPSP	DEG_COP1_1	704:711	Mutation altering degron motif	0.7785
p.D704V	ACH-002101	Lung Cancer	CCLE	DELVVPSP	DEG_COP1_1	704:711	Mutation altering degron motif	0.7785
p.D704V	EMC-BAC-1	lung	COSMIC	DELVVPSP	DEG_COP1_1	704:711	Mutation altering degron motif	0.7785
p.D281N	SIDM00863	Burkitt's Lymphoma	GDSC	VQLFPE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.2222
p.D697N	ACH-001521	Skin Cancer	CCLE	DELVVPSP	DEG_COP1_1	704:711	Mutation rewiring degron network	0.1389

Kaplan plot for BEND3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BEND3

UniProt ID: Q5T5X7

Entrez ID: 57673

Protein name: BEN domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BEND3 in