DegronMD

Uniprot ID: Q5T5X7

Source protein: BEN domain-containing protein 3

Source gene: BEND3

Class: LIG_APCC_ABBA_1

Location: 272:277

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5666

ASA_SCORE: 53.65

COIL: 0.2452

CONS_SCORE: 0.9752

DSS_SCORE: 0.016

HELIX: 0.7415

FCONS_SCORE: 1.2107

RIG_SCORE: 0.9116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G263V	TCGA-A6-6652	COAD	TCGA	VQLFPE	LIG_APCC_ABBA_1	0.0833
p.G263V	DO7946	COAD	ICGC	VQLFPE	LIG_APCC_ABBA_1	0.0833
p.V282M	TCGA-B5-A3FC	UCEC	TCGA	VQLFPE	LIG_APCC_ABBA_1	0.1944
p.V282M	DO41871	UCEC	ICGC	VQLFPE	LIG_APCC_ABBA_1	0.1944
p.R286W	TCGA-HV-AA8V	PAAD	TCGA	VQLFPE	LIG_APCC_ABBA_1	0.0833
p.R286W	DO223713	PAAD	ICGC	VQLFPE	LIG_APCC_ABBA_1	0.0833
p.D283Y	TCGA-WK-A8XT	SARC	TCGA	VQLFPE	LIG_APCC_ABBA_1	0.1667
p.D283Y	DO220298	SARC	ICGC	VQLFPE	LIG_APCC_ABBA_1	0.1667
p.E277K	DO233850	GACA	ICGC	VQLFPE	LIG_APCC_ABBA_1	0.7022
p.D283E	DO229035	LICA	ICGC	VQLFPE	LIG_APCC_ABBA_1	0.1667
p.G287V	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	VQLFPE	LIG_APCC_ABBA_1	0.0556
p.G287V	ACH-000015	Lung Cancer	CCLE	VQLFPE	LIG_APCC_ABBA_1	0.0556
p.G287V	NCI-H1581	lung	COSMIC	VQLFPE	LIG_APCC_ABBA_1	0.0556
p.D281N	SIDM00863	Burkitt's Lymphoma	GDSC	VQLFPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5X7	BEN domain-containing protein 3	LIG_APCC_ABBA_1	272:277	VQLFPE	APC,CDC20,FZR1	0.5666	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons