DegronMD

Uniprot ID: Q5T5X7

Source protein: BEN domain-containing protein 3

Source gene: BEND3

Class: DEG_COP1_1

Location: 704:711

E3 ligase: COP1

DEGRON score: 0.9124

ASA_SCORE: 80.55

COIL: 0.7975

CONS_SCORE: 0.8827

DSS_SCORE: 0.3436

HELIX: 0.1599

FCONS_SCORE: 0.9295

RIG_SCORE: 0.7485

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D704Y	TCGA-66-2793	LUSC	TCGA	DELVVPSP	DEG_COP1_1	0.7325
p.D704Y	DO27334	LUSC	ICGC	DELVVPSP	DEG_COP1_1	0.7325
p.P714L	TCGA-CA-5256	COAD	TCGA	DELVVPSP	DEG_COP1_1	0.25
p.P714L	DO10526	COAD	ICGC	DELVVPSP	DEG_COP1_1	0.25
p.P702L	TCGA-D6-6516	HNSC	TCGA	DELVVPSP	DEG_COP1_1	0.2778
p.P702L	DO15623	HNSC	ICGC	DELVVPSP	DEG_COP1_1	0.2778
p.P718S	TCGA-YD-A9TA	SKCM	TCGA	DELVVPSP	DEG_COP1_1	0.1389
p.P718S	DO219503	SKCM	ICGC	DELVVPSP	DEG_COP1_1	0.1389
p.P714S	DO229456	SKCA	ICGC	DELVVPSP	DEG_COP1_1	0.25
p.D712G	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DELVVPSP	DEG_COP1_1	0.3056
p.D712G	ACH-002272	Lymphoma	CCLE	DELVVPSP	DEG_COP1_1	0.3056
p.D712G	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DELVVPSP	DEG_COP1_1	0.3056
p.D704V	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DELVVPSP	DEG_COP1_1	0.7785
p.D704V	ACH-002101	Lung Cancer	CCLE	DELVVPSP	DEG_COP1_1	0.7785
p.D704V	EMC-BAC-1	lung	COSMIC	DELVVPSP	DEG_COP1_1	0.7785
p.D697N	ACH-001521	Skin Cancer	CCLE	DELVVPSP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5X7	BEN domain-containing protein 3	DEG_COP1_1	704:711	DELVVPSP	COP1	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons