DegronMD

Uniprot ID: Q15678

Source protein: Tyrosine-protein phosphatase non-receptor type 14

Source gene: PTPN14

Class: DEG_SCF_FBW7_2

Location: 441:446

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 84.2667

COIL: 0.7137

CONS_SCORE: 0.417

DSS_SCORE: 0.4269

HELIX: 0.2522

FCONS_SCORE: 1.3237

RIG_SCORE: 0.7391

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V436M	TCGA-A5-A0G2	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.1944
p.V436M	DO41235	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.1944
p.V436M	SIDM01181	Hepatocellular Carcinoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	0.1944
p.V436M	ACH-000221	Liver Cancer	CCLE	PTPDYE	DEG_SCF_FBW7_2	0.1944
p.V436M	SNU-398	liver	COSMIC	PTPDYE	DEG_SCF_FBW7_2	0.1944
p.P437S	TCGA-BR-7851	STAD	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.2222
p.P437S	DO38711	STAD	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.2222
p.D444Y	TCGA-D1-A165	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.6214
p.D444Y	DO41740	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.6214
p.I435T	TCGA-DI-A1BU	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.1667
p.I435T	DO42023	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.1667
p.K453N	TCGA-DK-A2HX	BLCA	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.25
p.K453N	DO473	BLCA	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.25
p.R450H	TCGA-EI-6882	READ	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.2222
p.R450H	DO36531	READ	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.2222
p.S438L	TCGA-EO-A22R	UCEC	TCGA	PTPDYE	DEG_SCF_FBW7_2	0.25
p.S438L	DO42713	UCEC	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.25
p.A433V	DO233634	GACA	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	SIDM01088	Endometrial Carcinoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	ACH-000583	Lymphoma	CCLE	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	ACH-000965	Endometrial/Uterine Cancer	CCLE	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	ACH-001638	Lymphoma	CCLE	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	RL95-2	endometrium	COSMIC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.A433V	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.T442N	DO229019	LICA	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.7055
p.A433T	DO228613	MALY	ICGC	PTPDYE	DEG_SCF_FBW7_2	0.1111
p.R450L	ACH-001750	Sarcoma	CCLE	PTPDYE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15678	Tyrosine-protein phosphatase non-receptor type 14	DEG_SCF_FBW7_2	441:446	PTPDYE	FBXW7	0.9995	More...
Q16825	Tyrosine-protein phosphatase non-receptor type 21	DEG_SCF_FBW7_2	447:452	PTPDYE	FBXW7	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPDYE

Degron related mutations and impact score

Drug responses associated with PTPN14 mutations

All proteins holding degron of PTPDYE