DegronMD

Uniprot ID: Q15678

Source protein: Tyrosine-protein phosphatase non-receptor type 14

Source gene: PTPN14

Class: LIG_APCC_ABBA_1

Location: 942:947

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9675

ASA_SCORE: 51.8667

COIL: 0.7705

CONS_SCORE: 0.6325

DSS_SCORE: 0.3337

HELIX: 0.0685

FCONS_SCORE: 1.1796

RIG_SCORE: 0.8104

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R940P	TCGA-04-1341	OV	TCGA	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.R940P	DO28017	OV	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.A934V	TCGA-AX-A0J0	UCEC	TCGA	VVPYEE	LIG_APCC_ABBA_1	0.1111
p.A934V	DO41133	UCEC	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.1111
p.A934T	TCGA-B0-5399	KIRC	TCGA	VVPYEE	LIG_APCC_ABBA_1	0.1111
p.A934T	DO19523	KIRC	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.1111
p.R949Q	TCGA-BG-A0MQ	UCEC	TCGA	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.R949Q	DO228416	LICA	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.R949Q	DO41127	UCEC	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.R940C	TCGA-XF-A9SZ	BLCA	TCGA	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.R940C	DO51919	BLCA	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.P954T	DO229045	LICA	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.1389
p.R940H	DO35120	PACA	ICGC	VVPYEE	LIG_APCC_ABBA_1	0.2778
p.R936C	SIDM00214	Colorectal Carcinoma	GDSC	VVPYEE	LIG_APCC_ABBA_1	0.1667
p.R936C	ACH-000955	Colon/Colorectal Cancer	CCLE	VVPYEE	LIG_APCC_ABBA_1	0.1667
p.R936C	SNU-407	large_intestine	COSMIC	VVPYEE	LIG_APCC_ABBA_1	0.1667
p.N948I	ACH-000872	Lung Cancer	CCLE	VVPYEE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15678	Tyrosine-protein phosphatase non-receptor type 14	LIG_APCC_ABBA_1	942:947	VVPYEE	APC,CDC20,FZR1	0.9675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons