DegronMD - P35498(SCN1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1901F	TCGA-16-0849	GBM	TCGA	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.2222
p.M1977V	TCGA-34-5239	LUSC	TCGA	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.1667
p.S1918C	TCGA-61-2012	OV	TCGA	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation blocking phosphorylation signal	0.5278
p.I1993V	TCGA-66-2766	LUSC	TCGA	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.1389
p.T1973S	TCGA-73-A9RS	LUAD	TCGA	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.0556
p.V1901L	TCGA-AA-3846	COAD	TCGA	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.2222
p.K1996T	TCGA-AX-A0J0	UCEC	TCGA	PPSY	ITCH	1983:1986	Mutation substituting flanking lysine	0.1667
p.P1898L	TCGA-BF-AAP2	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1389
p.D1987N	TCGA-CD-5800	STAD	TCGA	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.3056
p.D1987N	SIDM00670	Pancreatic Carcinoma	GDSC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.3056
p.D1987N	HPAC	pancreas	COSMIC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.3056
p.R1912Q	TCGA-D3-A1Q4	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.25
p.R1912Q	SIDM00007	Other Solid Cancers	GDSC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.25
p.R1912Q	MCC13	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.25
p.P1898H	TCGA-DF-A2KU	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1389
p.P1898H	DO223286	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1389
p.E1995K	TCGA-EB-A41A	SKCM	TCGA	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.0833
p.E1995K	DO37429	SKCM	ICGC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.0833
p.N1897S	TCGA-F7-A620	HNSC	TCGA	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1111
p.N1897S	DO44445	HNSC	ICGC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1111
p.R1913L	DO506	BLCA	ICGC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation substituting flanking lysine	0.3333
p.T1908A	DO223068	ESCA	ICGC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation altering degron motif	0.825
p.P1983Q	DO229019	LICA	ICGC	PPSY	ITCH	1983:1986	Mutation altering degron motif	0.7035
p.Q1988E	DO23360	LINC	ICGC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.2778
p.Q1904H	DO231204	LUSC	ICGC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.3056
p.I1982V	DO27747	LUSC	ICGC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.3056
p.S1907C	DO32536	OV	ICGC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation altering degron motif	0.7541
p.P1992S	DO229494	SKCA	ICGC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.1667
p.R1901Q	DO47631	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.2222
p.R1901Q	MCC13	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.2222
p.D1976N	DO38431	STAD	ICGC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.1389
p.D1976N	HPAC	pancreas	COSMIC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.1389
p.K1985T	DO41133	UCEC	ICGC	PPSY	ITCH	1983:1986	Mutation altering degron motif	0.7306
p.C1982F	SIDM00441	Acute Myeloid Leukemia	GDSC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.3056
p.C1982F	ML-2	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.3056
p.A1980T	SIDM01159	Other Sarcomas	GDSC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.25
p.A1980T	SW872	soft tissue	COSMIC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.25
p.P1984H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPSY	ITCH	1983:1986	Mutation altering degron motif	0.7694
p.G1980E	ACH-000579	Skin Cancer	CCLE	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.25
p.G1980E	UACC-257	skin	COSMIC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.25
p.A1897D	ACH-000654	Lymphoma	CCLE	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1111
p.A1897D	Raji	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1111
p.R1896H	ACH-000942	Leukemia	CCLE	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.0833
p.R1896H	ACH-000960	Leukemia	CCLE	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.0833
p.R1896H	REH	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.0833
p.G1914E	UACC-257	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1944
p.R1917C	GP5d	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1111
p.R1916C	GP5d	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1389
p.G1996E	UACC-257	skin	COSMIC	PPSY	ITCH	1983:1986	Mutation substituting flanking lysine	0.1667
p.R1913H	REH	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation substituting flanking lysine	0.3333
p.R1900Q	MCC13	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation substituting flanking lysine	0.3056
p.A1914D	Raji	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.1944
p.R1900C	GP5d	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation substituting flanking lysine	0.3056
p.D1975N	HPAC	pancreas	COSMIC	PPSY	ITCH	1983:1986	Mutation rewiring degron network	0.1111
p.A1913D	Raji	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation substituting flanking lysine	0.3333
p.R1912H	REH	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1905:1909	Mutation rewiring degron network	0.25

Kaplan plot for SCN1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN1A

UniProt ID: P35498

Entrez ID: 6323

Protein name: Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN1A in