DegronMD

Uniprot ID: P35498

Source protein: Sodium channel protein type 1 subunit alpha

Source gene: SCN1A

Class: DEG_SPOP_SBC_1

Location: 1905:1909

E3 ligase: SPOP

DEGRON score: 0.8856

ASA_SCORE: 63.42

COIL: 0.8532

CONS_SCORE: 0.3342

DSS_SCORE: 0.4406

HELIX: 0.0516

FCONS_SCORE: 0.9839

RIG_SCORE: 0.7851

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1901F	TCGA-16-0849	GBM	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.S1918C	TCGA-61-2012	OV	TCGA	PITTT	DEG_SPOP_SBC_1	0.5278
p.V1901L	TCGA-AA-3846	COAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.P1898L	TCGA-BF-AAP2	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	0.1389
p.R1912Q	TCGA-D3-A1Q4	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	0.25
p.R1912Q	SIDM00007	Other Solid Cancers	GDSC	PITTT	DEG_SPOP_SBC_1	0.25
p.R1912Q	MCC13	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	0.25
p.P1898H	TCGA-DF-A2KU	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	0.1389
p.P1898H	DO223286	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	0.1389
p.N1897S	TCGA-F7-A620	HNSC	TCGA	PITTT	DEG_SPOP_SBC_1	0.1111
p.N1897S	DO44445	HNSC	ICGC	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1913L	DO506	BLCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.3333
p.T1908A	DO223068	ESCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.825
p.Q1904H	DO231204	LUSC	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.S1907C	DO32536	OV	ICGC	PITTT	DEG_SPOP_SBC_1	0.7541
p.R1901Q	DO47631	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1901Q	MCC13	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	0.2222
p.A1897D	ACH-000654	Lymphoma	CCLE	PITTT	DEG_SPOP_SBC_1	0.1111
p.A1897D	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1896H	ACH-000942	Leukemia	CCLE	PITTT	DEG_SPOP_SBC_1	0.0833
p.R1896H	ACH-000960	Leukemia	CCLE	PITTT	DEG_SPOP_SBC_1	0.0833
p.R1896H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.0833
p.G1914E	UACC-257	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	0.1944
p.R1917C	GP5d	large_intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1916C	GP5d	large_intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	0.1389
p.R1913H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.3333
p.R1900Q	MCC13	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	0.3056
p.A1914D	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.1944
p.R1900C	GP5d	large_intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	0.3056
p.A1913D	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.3333
p.R1912H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1331:1335	PITTT	SPOP	0.6964	More...
P27338	Amine oxidase [flavin-containing] B	DEG_SPOP_SBC_1	476:480	PITTT	SPOP	0.8811	More...
P35498	Sodium channel protein type 1 subunit alpha	DEG_SPOP_SBC_1	1905:1909	PITTT	SPOP	0.8856	More...
P35499	Sodium channel protein type 4 subunit alpha	DEG_SPOP_SBC_1	1717:1721	PITTT	SPOP	0.9991	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1441:1445	PITTT	SPOP	0.7527	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1668:1672	PITTT	SPOP	0.5757	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1684:1688	PITTT	SPOP	0.7501	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1708:1712	PITTT	SPOP	0.5209	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1900:1904	PITTT	SPOP	0.9006	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1923:1927	PITTT	SPOP	0.9531	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1946:1950	PITTT	SPOP	0.9842	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1969:1973	PITTT	SPOP	0.9854	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1992:1996	PITTT	SPOP	0.9953	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2015:2019	PITTT	SPOP	0.9735	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2038:2042	PITTT	SPOP	0.9863	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2061:2065	PITTT	SPOP	0.9919	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2084:2088	PITTT	SPOP	0.9675	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2107:2111	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2130:2134	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2153:2157	PITTT	SPOP	0.9102	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2176:2180	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2199:2203	PITTT	SPOP	0.9635	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2222:2226	PITTT	SPOP	0.9973	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2245:2249	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2268:2272	PITTT	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2291:2295	PITTT	SPOP	0.9686	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2314:2318	PITTT	SPOP	0.9855	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2337:2341	PITTT	SPOP	0.9166	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2360:2364	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2383:2387	PITTT	SPOP	0.9202	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2406:2410	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2429:2433	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2452:2456	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2475:2479	PITTT	SPOP	0.9386	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2498:2502	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2521:2525	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2544:2548	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2567:2571	PITTT	SPOP	0.9779	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2590:2594	PITTT	SPOP	0.9969	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2613:2617	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2636:2640	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2659:2663	PITTT	SPOP	0.9452	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2682:2686	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2705:2709	PITTT	SPOP	0.9693	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2728:2732	PITTT	SPOP	0.9854	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2751:2755	PITTT	SPOP	0.9637	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2774:2778	PITTT	SPOP	0.9737	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2797:2801	PITTT	SPOP	0.9778	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2820:2824	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2843:2847	PITTT	SPOP	0.9519	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2866:2870	PITTT	SPOP	0.9702	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2889:2893	PITTT	SPOP	0.9637	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2912:2916	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2935:2939	PITTT	SPOP	0.9499	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2958:2962	PITTT	SPOP	0.9953	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2981:2985	PITTT	SPOP	0.9969	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3004:3008	PITTT	SPOP	0.9442	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3027:3031	PITTT	SPOP	0.9457	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3050:3054	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3073:3077	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3096:3100	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3119:3123	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3142:3146	PITTT	SPOP	0.9764	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3165:3169	PITTT	SPOP	0.9781	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3188:3192	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3211:3215	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3234:3238	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3257:3261	PITTT	SPOP	0.9764	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3280:3284	PITTT	SPOP	0.9773	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3303:3307	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3326:3330	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3349:3353	PITTT	SPOP	0.9693	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3372:3376	PITTT	SPOP	0.9442	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3395:3399	PITTT	SPOP	0.9686	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3418:3422	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3441:3445	PITTT	SPOP	0.9734	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3464:3468	PITTT	SPOP	0.9562	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3487:3491	PITTT	SPOP	0.9688	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3510:3514	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3533:3537	PITTT	SPOP	0.9734	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3556:3560	PITTT	SPOP	0.9466	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3579:3583	PITTT	SPOP	0.9166	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3602:3606	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3625:3629	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3648:3652	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3671:3675	PITTT	SPOP	0.9855	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3694:3698	PITTT	SPOP	0.9855	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3717:3721	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3740:3744	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3763:3767	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3786:3790	PITTT	SPOP	0.9779	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3809:3813	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3832:3836	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3855:3859	PITTT	SPOP	0.9443	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3878:3882	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3901:3905	PITTT	SPOP	0.9986	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3924:3928	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3947:3951	PITTT	SPOP	0.9945	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3970:3974	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3993:3997	PITTT	SPOP	0.9705	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4016:4020	PITTT	SPOP	0.9952	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4039:4043	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4062:4066	PITTT	SPOP	0.9166	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4085:4089	PITTT	SPOP	0.996	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4108:4112	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4131:4135	PITTT	SPOP	0.9102	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4154:4158	PITTT	SPOP	0.9947	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4177:4181	PITTT	SPOP	0.7932	More...
Q14524	Sodium channel protein type 5 subunit alpha	DEG_SPOP_SBC_1	1891:1895	PITTT	SPOP	0.9929	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1879:1883	PITTT	SPOP	0.9993	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1895:1899	PITTT	SPOP	0.9556	More...
Q9NY46	Sodium channel protein type 3 subunit alpha	DEG_SPOP_SBC_1	1890:1894	PITTT	SPOP	0.9728	More...
Q9UQD0	Sodium channel protein type 8 subunit alpha	DEG_SPOP_SBC_1	1885:1889	PITTT	SPOP	0.9919	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1859:1863	PITTT	SPOP	0.5477	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1898:1902	PITTT	SPOP	0.996	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1938:1942	PITTT	SPOP	0.7432	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1978:1982	PITTT	SPOP	0.9136	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2019:2023	PITTT	SPOP	0.9638	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2059:2063	PITTT	SPOP	0.8268	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITTT

Degron related mutations and impact score

Drug responses associated with SCN1A mutations

All proteins holding degron of PITTT