DegronMD

Uniprot ID: Q14524

Source protein: Sodium channel protein type 5 subunit alpha

Source gene: SCN5A

Class: DEG_SPOP_SBC_1

Location: 1891:1895

E3 ligase: SPOP

DEGRON score: 0.9929

ASA_SCORE: 64.62

COIL: 0.7898

CONS_SCORE: 0.304

DSS_SCORE: 0.4229

HELIX: 0.062

FCONS_SCORE: 0.9566

RIG_SCORE: 0.7755

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1892F	DO218874	SKCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.7982
p.Q1891R	KM12	large_intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	0.7329
p.A1895T	SNU-175	large_intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	0.7139
p.R1896H	DO8538	COAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1896H	DO50687	ORCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1896H	DO35442	PACA	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1890Q	DO222465	ESCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1886C	DO40996	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1886C	ACH-000773	Lymphoma	CCLE	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1886C	ACH-000887	Brain Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1886H	DO41235	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1886H	ACH-001738	Leukemia	CCLE	PITTT	DEG_SPOP_SBC_1	0.3056
p.Y1896C	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.3056
p.R1897Q	TCGA-C5-A1MF	CESC	TCGA	PITTT	DEG_SPOP_SBC_1	0.2778
p.V1897M	DO3095	BRCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.2778
p.R1897W	SIDM00854	Burkitt's Lymphoma	GDSC	PITTT	DEG_SPOP_SBC_1	0.2778
p.R1898C	TCGA-AA-A00N	COAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.25
p.S1888F	TCGA-B5-A11E	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	0.25
p.A1887T	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	0.2222
p.E1900D	HCC2998	large_intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	0.1944
p.E1901K	TCGA-AP-A0LM	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	0.1667
p.E1901K	TCGA-HU-A4H8	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.1667
p.P1884R	TCGA-DA-A95Z	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	0.1389
p.G1902V	DO45370	LUAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.1389
p.G1902S	DO47849	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.1389

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Drug responses associated with SCN5A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PITTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27338	Amine oxidase [flavin-containing] B	DEG_SPOP_SBC_1	476:480	PITTT	SPOP	0.8811	More...
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1331:1335	PITTT	SPOP	0.6964	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1441:1445	PITTT	SPOP	0.7527	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1668:1672	PITTT	SPOP	0.5757	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1684:1688	PITTT	SPOP	0.7501	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1708:1712	PITTT	SPOP	0.5209	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1900:1904	PITTT	SPOP	0.9006	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1923:1927	PITTT	SPOP	0.9531	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1946:1950	PITTT	SPOP	0.9842	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1969:1973	PITTT	SPOP	0.9854	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1992:1996	PITTT	SPOP	0.9953	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2015:2019	PITTT	SPOP	0.9735	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2038:2042	PITTT	SPOP	0.9863	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2061:2065	PITTT	SPOP	0.9919	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2084:2088	PITTT	SPOP	0.9675	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2107:2111	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2130:2134	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2153:2157	PITTT	SPOP	0.9102	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2176:2180	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2199:2203	PITTT	SPOP	0.9635	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2222:2226	PITTT	SPOP	0.9973	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2245:2249	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2268:2272	PITTT	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2291:2295	PITTT	SPOP	0.9686	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2314:2318	PITTT	SPOP	0.9855	More...

Showing 1 to 25 of 119 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITTT

Degron related mutations and impact score

Drug responses associated with SCN5A mutations

All proteins holding degron of PITTT