DegronMD

Uniprot ID: Q15858

Source protein: Sodium channel protein type 9 subunit alpha

Source gene: SCN9A

Class: DEG_SPOP_SBC_1

Location: 1879:1883

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 66.66

COIL: 0.8182

CONS_SCORE: 0.3602

DSS_SCORE: 0.4756

HELIX: 0.032

FCONS_SCORE: 1.0599

RIG_SCORE: 0.7735

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1891P	TCGA-06-0213	GBM	TCGA	PITTT	DEG_SPOP_SBC_1	0.1111
p.S1881F	TCGA-18-3409	LUSC	TCGA	PITTT	DEG_SPOP_SBC_1	0.7982
p.R1891H	TCGA-27-2519	GBM	TCGA	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1891H	TCGA-AP-A059	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1891H	SIDM00670	Pancreatic Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1891H	ACH-000270	Pancreatic Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1891H	ACH-001098	Pancreatic Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1891C	TCGA-3U-A98D	MESO	TCGA	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1891C	TCGA-FI-A2D0	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	0.1111
p.R1875W	TCGA-AA-3855	COAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1875W	TCGA-BR-8360	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1875W	TCGA-HU-A4G6	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1875W	TCGA-TM-A84B	LGG	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1890I	TCGA-AX-A2HD	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	0.1389
p.R1875Q	TCGA-BR-A4J5	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1875Q	TCGA-F5-6814	READ	TCGA	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1875Q	SIDM00190	Melanoma	GDSC	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1875Q	ACH-002097	Skin Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	0.2222
p.R1875Q	CP66-MEL	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	0.2222
p.I1869M	TCGA-CN-4728	HNSC	TCGA	PITTT	DEG_SPOP_SBC_1	0.0556
p.D1879N	TCGA-EE-A29M	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	0.6932
p.A1882V	TCGA-FP-A4BE	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.6936
p.R1887L	TCGA-MN-A4N4	LUAD	TCGA	PITTT	DEG_SPOP_SBC_1	0.3333
p.T1882N	DO227935	BRCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.8166
p.T1882N	DO229028	LICA	ICGC	PITTT	DEG_SPOP_SBC_1	0.8166
p.R1886W	DO10742	COAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.25
p.R1886W	DO50230	LGG	ICGC	PITTT	DEG_SPOP_SBC_1	0.25
p.R1886W	DO47747	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.25
p.R1886W	DO47745	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.25
p.T1882P	DO10324	COAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.8142
p.P1872H	DO8224	COAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.1389
p.A1870S	DO13911	GBM	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.A1870S	DO41879	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.I1880M	DO15799	HNSC	ICGC	PITTT	DEG_SPOP_SBC_1	0.6507
p.S1869Y	DO20633	KIRC	ICGC	PITTT	DEG_SPOP_SBC_1	0.0556
p.S1869Y	DO41109	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	0.0556
p.S1892F	DO26444	LUSC	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.V1891M	DO52687	MALY	ICGC	PITTT	DEG_SPOP_SBC_1	0.1111
p.P1872S	DO222843	MELA	ICGC	PITTT	DEG_SPOP_SBC_1	0.1389
p.P1872S	DO47331	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	0.1389
p.R1886Q	DO36556	READ	ICGC	PITTT	DEG_SPOP_SBC_1	0.25
p.R1886Q	DO38185	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.25
p.R1886Q	CP66-MEL	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	0.25
p.P1879L	DO218904	SKCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.7582
p.D1890N	DO37404	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	0.1389
p.A1893V	DO48016	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.0556
p.A1870T	DO229245	THCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.R1893H	SIDM00581	Glioblastoma	GDSC	PITTT	DEG_SPOP_SBC_1	0.0556
p.R1893H	SIDM00928	Breast Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	0.0556
p.R1893H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PITTT	DEG_SPOP_SBC_1	0.0556
p.R1893H	SIDM00024	Non-Cancerous	GDSC	PITTT	DEG_SPOP_SBC_1	0.0556
p.R1893H	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	0.0556
p.A1882D	ACH-001184	Sarcoma	CCLE	PITTT	DEG_SPOP_SBC_1	0.7793
p.R1887C	ACH-001786	Colon/Colorectal Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	0.3333
p.A1881V	SNU-C2B	large_intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	0.6936
p.S1873F	IPC-298	skin	COSMIC	PITTT	DEG_SPOP_SBC_1	0.6111
p.M1880T	NCI-H1105	lung	COSMIC	PITTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1331:1335	PITTT	SPOP	0.6964	More...
P27338	Amine oxidase [flavin-containing] B	DEG_SPOP_SBC_1	476:480	PITTT	SPOP	0.8811	More...
P35498	Sodium channel protein type 1 subunit alpha	DEG_SPOP_SBC_1	1905:1909	PITTT	SPOP	0.8856	More...
P35499	Sodium channel protein type 4 subunit alpha	DEG_SPOP_SBC_1	1717:1721	PITTT	SPOP	0.9991	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1441:1445	PITTT	SPOP	0.7527	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1668:1672	PITTT	SPOP	0.5757	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1684:1688	PITTT	SPOP	0.7501	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1708:1712	PITTT	SPOP	0.5209	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1900:1904	PITTT	SPOP	0.9006	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1923:1927	PITTT	SPOP	0.9531	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1946:1950	PITTT	SPOP	0.9842	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1969:1973	PITTT	SPOP	0.9854	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1992:1996	PITTT	SPOP	0.9953	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2015:2019	PITTT	SPOP	0.9735	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2038:2042	PITTT	SPOP	0.9863	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2061:2065	PITTT	SPOP	0.9919	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2084:2088	PITTT	SPOP	0.9675	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2107:2111	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2130:2134	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2153:2157	PITTT	SPOP	0.9102	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2176:2180	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2199:2203	PITTT	SPOP	0.9635	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2222:2226	PITTT	SPOP	0.9973	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2245:2249	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2268:2272	PITTT	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2291:2295	PITTT	SPOP	0.9686	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2314:2318	PITTT	SPOP	0.9855	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2337:2341	PITTT	SPOP	0.9166	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2360:2364	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2383:2387	PITTT	SPOP	0.9202	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2406:2410	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2429:2433	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2452:2456	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2475:2479	PITTT	SPOP	0.9386	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2498:2502	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2521:2525	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2544:2548	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2567:2571	PITTT	SPOP	0.9779	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2590:2594	PITTT	SPOP	0.9969	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2613:2617	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2636:2640	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2659:2663	PITTT	SPOP	0.9452	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2682:2686	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2705:2709	PITTT	SPOP	0.9693	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2728:2732	PITTT	SPOP	0.9854	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2751:2755	PITTT	SPOP	0.9637	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2774:2778	PITTT	SPOP	0.9737	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2797:2801	PITTT	SPOP	0.9778	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2820:2824	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2843:2847	PITTT	SPOP	0.9519	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2866:2870	PITTT	SPOP	0.9702	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2889:2893	PITTT	SPOP	0.9637	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2912:2916	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2935:2939	PITTT	SPOP	0.9499	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2958:2962	PITTT	SPOP	0.9953	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2981:2985	PITTT	SPOP	0.9969	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3004:3008	PITTT	SPOP	0.9442	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3027:3031	PITTT	SPOP	0.9457	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3050:3054	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3073:3077	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3096:3100	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3119:3123	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3142:3146	PITTT	SPOP	0.9764	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3165:3169	PITTT	SPOP	0.9781	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3188:3192	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3211:3215	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3234:3238	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3257:3261	PITTT	SPOP	0.9764	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3280:3284	PITTT	SPOP	0.9773	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3303:3307	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3326:3330	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3349:3353	PITTT	SPOP	0.9693	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3372:3376	PITTT	SPOP	0.9442	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3395:3399	PITTT	SPOP	0.9686	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3418:3422	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3441:3445	PITTT	SPOP	0.9734	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3464:3468	PITTT	SPOP	0.9562	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3487:3491	PITTT	SPOP	0.9688	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3510:3514	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3533:3537	PITTT	SPOP	0.9734	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3556:3560	PITTT	SPOP	0.9466	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3579:3583	PITTT	SPOP	0.9166	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3602:3606	PITTT	SPOP	0.9696	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3625:3629	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3648:3652	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3671:3675	PITTT	SPOP	0.9855	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3694:3698	PITTT	SPOP	0.9855	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3717:3721	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3740:3744	PITTT	SPOP	0.9719	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3763:3767	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3786:3790	PITTT	SPOP	0.9779	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3809:3813	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3832:3836	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3855:3859	PITTT	SPOP	0.9443	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3878:3882	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3901:3905	PITTT	SPOP	0.9986	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3924:3928	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3947:3951	PITTT	SPOP	0.9945	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3970:3974	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	3993:3997	PITTT	SPOP	0.9705	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4016:4020	PITTT	SPOP	0.9952	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4039:4043	PITTT	SPOP	0.9796	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4062:4066	PITTT	SPOP	0.9166	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4085:4089	PITTT	SPOP	0.996	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4108:4112	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4131:4135	PITTT	SPOP	0.9102	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4154:4158	PITTT	SPOP	0.9947	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4177:4181	PITTT	SPOP	0.7932	More...
Q14524	Sodium channel protein type 5 subunit alpha	DEG_SPOP_SBC_1	1891:1895	PITTT	SPOP	0.9929	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1879:1883	PITTT	SPOP	0.9993	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1895:1899	PITTT	SPOP	0.9556	More...
Q9NY46	Sodium channel protein type 3 subunit alpha	DEG_SPOP_SBC_1	1890:1894	PITTT	SPOP	0.9728	More...
Q9UQD0	Sodium channel protein type 8 subunit alpha	DEG_SPOP_SBC_1	1885:1889	PITTT	SPOP	0.9919	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1859:1863	PITTT	SPOP	0.5477	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1898:1902	PITTT	SPOP	0.996	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1938:1942	PITTT	SPOP	0.7432	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1978:1982	PITTT	SPOP	0.9136	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2019:2023	PITTT	SPOP	0.9638	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2059:2063	PITTT	SPOP	0.8268	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITTT

Degron related mutations and impact score

Drug responses associated with SCN9A mutations

All proteins holding degron of PITTT