DegronMD - P35499(SCN4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A2P	TCGA-33-4566	LUSC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6392
p.A2P	DO26790	LUSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6392
p.S1711Y	TCGA-44-8119	LUAD	TCGA	PITTT	DEG_SPOP_SBC_1	1717:1721	Mutation blocking phosphorylation signal	0.6111
p.S1711Y	DO24399	LUAD	ICGC	PITTT	DEG_SPOP_SBC_1	1717:1721	Mutation blocking phosphorylation signal	0.6111
p.L17M	TCGA-99-8025	LUAD	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1389
p.L17M	DO24255	LUAD	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1389
p.R18C	TCGA-B5-A11E	UCEC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	DO41644	UCEC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM00425	Ovarian Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM00492	Glioblastoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM00591	Oral Cavity Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM01617	Endometrial Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM01470	Acute Myeloid Leukemia	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM01432	Kidney Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18C	SIDM01469	Pancreatic Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.L9M	TCGA-BR-6852	STAD	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.5999
p.L9M	DO38202	STAD	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.5999
p.R18H	TCGA-CM-5344	COAD	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18H	DO10252	COAD	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.P11S	TCGA-D6-6516	HNSC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.3056
p.P11S	DO15623	HNSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.3056
p.L12M	TCGA-DJ-A2PX	THCA	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.2778
p.L12M	DO39683	THCA	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.2778
p.S5F	TCGA-EO-A3B0	UCEC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6871
p.S5F	DO219773	UCEC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6871
p.A2S	DO230998	LUSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6477
p.A2S	DO224576	LUSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation altering degron motif	0.6477
p.L12P	SIDM02050	Colorectal Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.2778
p.R18L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18L	ACH-000414	Lung Cancer	CCLE	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18L	NCI-H1944	lung	COSMIC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18S	SIDM01228	Melanoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.R18S	SIDM01517	Head and Neck Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.1111
p.A1731T	SIDM01735	Biliary Tract Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	1717:1721	Mutation rewiring degron network	0.0556
p.P19T	TE-9	oesophagus	COSMIC	ARPSLCTLV	DEG_APCC_DBOX_1	2:10	Mutation rewiring degron network	0.0833

Kaplan plot for SCN4A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN4A

UniProt ID: P35499

Entrez ID: 6329

Protein name: Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN4A in