DegronMD

Uniprot ID: P35499

Source protein: Sodium channel protein type 4 subunit alpha

Source gene: SCN4A

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9899

ASA_SCORE: 76.0222

COIL: 0.8639

CONS_SCORE: 0.2496

DSS_SCORE: 0.4871

HELIX: 0.0706

FCONS_SCORE: 0.8453

RIG_SCORE: 0.7882

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2P	TCGA-33-4566	LUSC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.6392
p.A2P	DO26790	LUSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.6392
p.L17M	TCGA-99-8025	LUAD	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.1389
p.L17M	DO24255	LUAD	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1389
p.R18C	TCGA-B5-A11E	UCEC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	DO41644	UCEC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM00425	Ovarian Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM00492	Glioblastoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM00591	Oral Cavity Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM01617	Endometrial Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM01470	Acute Myeloid Leukemia	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM01432	Kidney Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18C	SIDM01469	Pancreatic Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.L9M	TCGA-BR-6852	STAD	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.5999
p.L9M	DO38202	STAD	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.5999
p.R18H	TCGA-CM-5344	COAD	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18H	DO10252	COAD	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.P11S	TCGA-D6-6516	HNSC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.3056
p.P11S	DO15623	HNSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.3056
p.L12M	TCGA-DJ-A2PX	THCA	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.2778
p.L12M	DO39683	THCA	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.2778
p.S5F	TCGA-EO-A3B0	UCEC	TCGA	ARPSLCTLV	DEG_APCC_DBOX_1	0.6871
p.S5F	DO219773	UCEC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.6871
p.A2S	DO230998	LUSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.6477
p.A2S	DO224576	LUSC	ICGC	ARPSLCTLV	DEG_APCC_DBOX_1	0.6477
p.L12P	SIDM02050	Colorectal Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.2778
p.R18L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18L	ACH-000414	Lung Cancer	CCLE	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18L	NCI-H1944	lung	COSMIC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18S	SIDM01228	Melanoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.R18S	SIDM01517	Head and Neck Carcinoma	GDSC	ARPSLCTLV	DEG_APCC_DBOX_1	0.1111
p.P19T	TE-9	oesophagus	COSMIC	ARPSLCTLV	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPSLCTLV

Degron related mutations and impact score

Drug responses associated with SCN4A mutations

All proteins holding degron of ARPSLCTLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35499	Sodium channel protein type 4 subunit alpha	DEG_APCC_DBOX_1	2:10	ARPSLCTLV	APC,CDC20,FZR1	0.9899	More...