DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SPOP_SBC_1

Location: 1684:1688

E3 ligase: SPOP

DEGRON score: 0.7501

ASA_SCORE: 102.28

COIL: 0.9368

CONS_SCORE: 0.2919

DSS_SCORE: 0.7735

HELIX: 0.0096

FCONS_SCORE: 0.9709

RIG_SCORE: 0.5899

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1688S	DO229006	LICA	ICGC	PITTT	DEG_SPOP_SBC_1	0.6752
p.T1683M	DO224661	COCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.T1683M	DO224801	COCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.T1683M	DO232594	PBCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.3056
p.P1690H	TCGA-PK-A5HB	ACC	TCGA	PITTT	DEG_SPOP_SBC_1	0.2778
p.P1690L	DO38187	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	0.2778
p.G1682D	DO41241	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	0.2778
p.P1675L	DO224739	COCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.P1675T	DO222571	COCA	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.P1675T	DO49531	LAML	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.P1675T	DO229024	LICA	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833
p.P1675T	DO229006	LICA	ICGC	PITTT	DEG_SPOP_SBC_1	0.0833

Showing 1 to 12 of 12 entries

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Drug responses associated with MUC2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PITTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27338	Amine oxidase [flavin-containing] B	DEG_SPOP_SBC_1	476:480	PITTT	SPOP	0.8811	More...
A5YKK6	CCR4-NOT transcription complex subunit 1	DEG_SPOP_SBC_1	1331:1335	PITTT	SPOP	0.6964	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1441:1445	PITTT	SPOP	0.7527	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1668:1672	PITTT	SPOP	0.5757	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1684:1688	PITTT	SPOP	0.7501	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1708:1712	PITTT	SPOP	0.5209	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1900:1904	PITTT	SPOP	0.9006	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1923:1927	PITTT	SPOP	0.9531	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1946:1950	PITTT	SPOP	0.9842	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1969:1973	PITTT	SPOP	0.9854	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1992:1996	PITTT	SPOP	0.9953	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2015:2019	PITTT	SPOP	0.9735	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2038:2042	PITTT	SPOP	0.9863	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2061:2065	PITTT	SPOP	0.9919	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2084:2088	PITTT	SPOP	0.9675	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2107:2111	PITTT	SPOP	0.9639	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2130:2134	PITTT	SPOP	0.9712	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2153:2157	PITTT	SPOP	0.9102	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2176:2180	PITTT	SPOP	0.9799	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2199:2203	PITTT	SPOP	0.9635	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2222:2226	PITTT	SPOP	0.9973	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2245:2249	PITTT	SPOP	0.9971	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2268:2272	PITTT	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2291:2295	PITTT	SPOP	0.9686	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	2314:2318	PITTT	SPOP	0.9855	More...

Showing 1 to 25 of 119 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITTT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of PITTT