DegronMD - Q14524(SCN5A)

GO - Biological processes (BP): atrial cardiac muscle cell action potential [GO:0086014]; AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell communication [GO:0086067]; brainstem development [GO:0003360]; bundle of His cell action potential [GO:0086043]; cardiac conduction system development [GO:0003161]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cardiac ventricle development [GO:0003231]; cellular response to calcium ion [GO:0071277]; cerebellum development [GO:0021549]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; membrane depolarization during SA node cell action potential [GO:0086046]; neuronal action potential [GO:0019228]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of action potential [GO:0045760]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537]; ventricular cardiac muscle cell action potential [GO:0086005] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E30K	TCGA-13-2060	OV	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1944
p.E30K	DO30170	OV	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1944
p.R15S	TCGA-22-1016	LUSC	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.R15S	DO26971	LUSC	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.G638S	TCGA-2Y-A9GW	LIHC	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1667
p.G638S	DO219511	LIHC	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1667
p.G639R	TCGA-52-7811	LUSC	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.G639R	DO26569	LUSC	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.E19Q	TCGA-98-A53I	LUSC	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.5633
p.E19Q	DO219182	LUSC	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.5633
p.S1985G	TCGA-A5-A2K5	UCEC	TCGA	PPSY	ITCH	1974:1977	Mutation blocking phosphorylation signal	0.5556
p.R1898C	TCGA-AA-A00N	COAD	TCGA	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.25
p.A1983S	TCGA-AG-3892	READ	TCGA	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.1667
p.R27H	TCGA-AJ-A5DW	UCEC	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.R27H	TCGA-D7-A6EY	STAD	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.R27H	DO225398	BRCA	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.R27H	DO50118	STAD	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.R27H	DO50075	UCEC	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.E1901K	TCGA-AP-A0LM	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1667
p.E1901K	TCGA-HU-A4H8	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1667
p.R34H	TCGA-AX-A2HA	UCEC	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34H	DO42504	UCEC	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.S1888F	TCGA-B5-A11E	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.25
p.D1978H	TCGA-BR-8080	STAD	TCGA	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.D1978H	SIDM00568	Gastric Carcinoma	GDSC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.D1978H	ACH-000247	Gastric Cancer	CCLE	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.D1978H	OCUM-1	stomach	COSMIC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.R1897Q	TCGA-C5-A1MF	CESC	TCGA	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.2778
p.N1987I	TCGA-D9-A6EA	SKCM	TCGA	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.0556
p.P1884R	TCGA-DA-A95Z	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1389
p.R14C	TCGA-DF-A2KU	UCEC	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.25
p.R14C	DO223286	UCEC	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.25
p.R14C	SIDM01086	B-Lymphoblastic Leukemia	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.25
p.R14C	ACH-000874	Leukemia	CCLE	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.25
p.R14C	RS4-11	haematopoietic and lymphoid tissue	COSMIC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.25
p.G639W	TCGA-DZ-6133	KIRP	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.G639W	DO20762	KIRP	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.G639W	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.G639W	ACH-000916	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.G639W	NCI-H1573	lung	COSMIC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.P627Q	TCGA-DZ-6133	KIRP	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.3056
p.P627Q	DO20762	KIRP	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.3056
p.D1986N	TCGA-EE-A181	SKCM	TCGA	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.0833
p.R8W	TCGA-EE-A2MS	SKCM	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R8W	DO37567	SKCM	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R27C	TCGA-HT-A5RC	LGG	TCGA	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.R27C	DO48525	LGG	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2778
p.E635D	TCGA-HU-A4GT	STAD	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.25
p.E635D	DO48020	STAD	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.25
p.F1956V	TCGA-IC-A6RE	ESCA	TCGA	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1667
p.E635Q	TCGA-KU-A66S	HNSC	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.25
p.E635Q	DO44456	HNSC	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.25
p.E635Q	SIDM00111	Glioma	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.25
p.E635Q	ACH-000232	Brain Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.25
p.E635Q	U251	central nervous system	COSMIC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.25
p.N1987S	TCGA-L5-A8NM	ESCA	TCGA	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.0556
p.M642L	TCGA-VQ-A91K	STAD	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.0556
p.M642L	DO51785	STAD	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.0556
p.R620C	TCGA-VQ-A925	STAD	TCGA	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1111
p.R620C	DO51796	STAD	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1111
p.V1897M	DO3095	BRCA	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.2778
p.R1958W	DO9314	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.R1958W	DO223064	ESCA	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.R1958W	DO42033	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.R1958W	DO42256	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.R1958W	ACH-000955	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.R1958W	SNU-407	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.A1969T	DO50092	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.25
p.A1969T	DO50092	COAD	ICGC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.1944
p.P1975L	DO7882	COAD	ICGC	PPSY	ITCH	1974:1977	Mutation altering degron motif	0.7582
p.R1896H	DO8538	COAD	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.3056
p.R1896H	DO50687	ORCA	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.3056
p.R1896H	DO35442	PACA	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.3056
p.E25K	DO222835	COCA	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.591
p.R1890Q	DO222465	ESCA	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.3056
p.A29V	DO233113	GACA	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2222
p.M28I	DO233613	GACA	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.25
p.S1960C	DO233876	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2778
p.P621L	DO233885	GACA	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.P621L	DO229232	THCA	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.A29T	DO233867	GACA	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.2222
p.H626P	DO225418	LAML	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-000054	Sarcoma	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-000136	Neuroblastoma	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-000416	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-001086	Cervical Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-002133	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-002213	Head and Neck Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-002248	Neuroblastoma	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626P	ACH-002388	Skin Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.T10N	DO231972	LICA	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1389
p.L624Q	DO228848	LICA	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2222
p.G9V	DO23374	LINC	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1111
p.G1902V	DO45370	LUAD	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1389
p.K31Q	DO230554	LUSC	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation substituting flanking lysine	0.2778
p.D1955E	DO26602	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1389
p.R18W	DO228869	MALY	ICGC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.8634
p.H626R	DO220851	MELA	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626R	ACH-001605	Brain Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.H626R	no-10	central nervous system	COSMIC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.L1968F	DO220891	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2778
p.L1968F	DO220891	MELA	ICGC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.1667
p.L1968F	DO222327	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2778
p.L1968F	DO222327	STAD	ICGC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.1667
p.E1966K	DO222615	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation altering degron motif	0.7022
p.E1966K	DO38177	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation altering degron motif	0.7022
p.S634L	DO222731	MELA	ICGC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.2778
p.P1973H	DO51380	PRAD	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1389
p.P1973H	DO51380	PRAD	ICGC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.S1892F	DO218874	SKCA	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation altering degron motif	0.7982
p.D1978N	DO37631	SKCM	ICGC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.D1955N	DO37762	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1389
p.D1953N	DO37444	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.0833
p.P1972S	DO51298	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1667
p.P1972S	DO51298	SKCM	ICGC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.2778
p.V1983M	DO38404	STAD	ICGC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.1667
p.G1902S	DO47849	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1389
p.R1958Q	DO40801	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.R1958Q	KYSE-520	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.R1886C	DO40996	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation substituting flanking lysine	0.3056
p.R1886C	ACH-000773	Lymphoma	CCLE	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation substituting flanking lysine	0.3056
p.R1886C	ACH-000887	Brain Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation substituting flanking lysine	0.3056
p.R1886H	DO41235	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation substituting flanking lysine	0.3056
p.R1886H	ACH-001738	Leukemia	CCLE	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation substituting flanking lysine	0.3056
p.S1952G	DO41379	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.0556
p.R34C	SIDM00969	Ovarian Carcinoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM00087	Plasma Cell Myeloma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM00650	Small Cell Lung Carcinoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM00498	Colorectal Carcinoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM00539	Esophageal Carcinoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM00793	Burkitt's Lymphoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM01681	Non-Cancerous	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.R34C	SIDM01689	B-Lymphoblastic Leukemia	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0833
p.S11I	SIDM00293	Small Cell Lung Carcinoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.6111
p.S11I	ACH-002052	Lung Cancer	CCLE	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.6111
p.S11I	LU-139	lung	COSMIC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.6111
p.L618F	SIDM00690	Head and Neck Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.0556
p.L618F	SIDM00694	Other Solid Cancers	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.0556
p.L618F	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.0556
p.L618F	SIDM00068	Colorectal Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.0556
p.T630M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation altering degron motif	0.7423
p.T630M	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation altering degron motif	0.7423
p.R1897W	SIDM00854	Burkitt's Lymphoma	GDSC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.2778
p.G35S	SIDM00063	Melanoma	GDSC	TRESLAAIE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.0556
p.E1954D	SIDM00118	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1111
p.E1954D	HCC2998	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1111
p.G639V	SIDM01503	Small Cell Lung Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.G639V	ACH-000844	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1389
p.P1974Q	SIDM01611	Endometrial Carcinoma	GDSC	PPSY	ITCH	1974:1977	Mutation altering degron motif	0.7035
p.R620H	SIDM01665	Colorectal Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1111
p.R620H	ACH-000089	Colon/Colorectal Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	628:632	Mutation rewiring degron network	0.1111
p.R1979C	ACH-000227	Neuroblastoma	CCLE	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.2778
p.R1979C	KP-N-YN	autonomic ganglia	COSMIC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.2778
p.E1905K	ACH-000533	Rhabdoid	CCLE	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.0556
p.E1905K	ACH-000991	Colon/Colorectal Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.0556
p.E1905K	SNU-81	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.0556
p.R1973W	SNU-407	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1389
p.R1973W	SNU-407	large intestine	COSMIC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.A1895T	SNU-175	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation altering degron motif	0.7139
p.R1958C	KP-N-YN	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2222
p.A1887T	L-428	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.2222
p.D1960H	OCUM-1	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.2778
p.R1973Q	KYSE-520	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.1389
p.R1973Q	KYSE-520	oesophagus	COSMIC	PPSY	ITCH	1974:1977	Mutation rewiring degron network	0.3056
p.E1884K	SNU-81	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1389
p.E1900D	HCC2998	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1944
p.Q1891R	KM12	large intestine	COSMIC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation altering degron motif	0.7329
p.E1953D	HCC2998	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	1962:1966	Mutation rewiring degron network	0.0833
p.Y1896C	BC-1	haematopoietic and lymphoid tissue	COSMIC	PITTT	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.3056
p.D1977H	OCUM-1	stomach	COSMIC	PPSY	ITCH	1974:1977	Mutation altering degron motif	0.7688

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN5A

UniProt ID: Q14524

Entrez ID: 6331

Protein name: Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN5A in