DegronMD

Uniprot ID: Q14524

Source protein: Sodium channel protein type 5 subunit alpha

Source gene: SCN5A

Class: DEG_SPOP_SBC_1

Location: 628:632

E3 ligase: SPOP

DEGRON score: 0.914

ASA_SCORE: 97.72

COIL: 0.968

CONS_SCORE: 0.276

DSS_SCORE: 0.8314

HELIX: 0.0208

FCONS_SCORE: 0.9962

RIG_SCORE: 0.5908

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G638S	TCGA-2Y-A9GW	LIHC	TCGA	PDTTT	DEG_SPOP_SBC_1	0.1667
p.G638S	DO219511	LIHC	ICGC	PDTTT	DEG_SPOP_SBC_1	0.1667
p.G639R	TCGA-52-7811	LUSC	TCGA	PDTTT	DEG_SPOP_SBC_1	0.1389
p.G639R	DO26569	LUSC	ICGC	PDTTT	DEG_SPOP_SBC_1	0.1389
p.G639W	TCGA-DZ-6133	KIRP	TCGA	PDTTT	DEG_SPOP_SBC_1	0.1389
p.G639W	DO20762	KIRP	ICGC	PDTTT	DEG_SPOP_SBC_1	0.1389
p.G639W	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	0.1389
p.G639W	ACH-000916	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.1389
p.G639W	NCI-H1573	lung	COSMIC	PDTTT	DEG_SPOP_SBC_1	0.1389
p.P627Q	TCGA-DZ-6133	KIRP	TCGA	PDTTT	DEG_SPOP_SBC_1	0.3056
p.P627Q	DO20762	KIRP	ICGC	PDTTT	DEG_SPOP_SBC_1	0.3056
p.E635D	TCGA-HU-A4GT	STAD	TCGA	PDTTT	DEG_SPOP_SBC_1	0.25
p.E635D	DO48020	STAD	ICGC	PDTTT	DEG_SPOP_SBC_1	0.25
p.E635Q	TCGA-KU-A66S	HNSC	TCGA	PDTTT	DEG_SPOP_SBC_1	0.25
p.E635Q	DO44456	HNSC	ICGC	PDTTT	DEG_SPOP_SBC_1	0.25
p.E635Q	SIDM00111	Glioma	GDSC	PDTTT	DEG_SPOP_SBC_1	0.25
p.E635Q	ACH-000232	Brain Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.25
p.E635Q	U251	central_nervous_system	COSMIC	PDTTT	DEG_SPOP_SBC_1	0.25
p.M642L	TCGA-VQ-A91K	STAD	TCGA	PDTTT	DEG_SPOP_SBC_1	0.0556
p.M642L	DO51785	STAD	ICGC	PDTTT	DEG_SPOP_SBC_1	0.0556
p.R620C	TCGA-VQ-A925	STAD	TCGA	PDTTT	DEG_SPOP_SBC_1	0.1111
p.R620C	DO51796	STAD	ICGC	PDTTT	DEG_SPOP_SBC_1	0.1111
p.P621L	DO233885	GACA	ICGC	PDTTT	DEG_SPOP_SBC_1	0.1389
p.P621L	DO229232	THCA	ICGC	PDTTT	DEG_SPOP_SBC_1	0.1389
p.H626P	DO225418	LAML	ICGC	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-000054	Sarcoma	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-000136	Neuroblastoma	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-000416	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-001086	Cervical Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-002133	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-002213	Head and Neck Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-002248	Neuroblastoma	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626P	ACH-002388	Skin Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.L624Q	DO228848	LICA	ICGC	PDTTT	DEG_SPOP_SBC_1	0.2222
p.H626R	DO220851	MELA	ICGC	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626R	ACH-001605	Brain Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.2778
p.H626R	no-10	central_nervous_system	COSMIC	PDTTT	DEG_SPOP_SBC_1	0.2778
p.S634L	DO222731	MELA	ICGC	PDTTT	DEG_SPOP_SBC_1	0.2778
p.L618F	SIDM00690	Head and Neck Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	0.0556
p.L618F	SIDM00694	Other Solid Cancers	GDSC	PDTTT	DEG_SPOP_SBC_1	0.0556
p.L618F	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	0.0556
p.L618F	SIDM00068	Colorectal Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	0.0556
p.T630M	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PDTTT	DEG_SPOP_SBC_1	0.7423
p.T630M	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PDTTT	DEG_SPOP_SBC_1	0.7423
p.G639V	SIDM01503	Small Cell Lung Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	0.1389
p.G639V	ACH-000844	Lung Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.1389
p.R620H	SIDM01665	Colorectal Carcinoma	GDSC	PDTTT	DEG_SPOP_SBC_1	0.1111
p.R620H	ACH-000089	Colon/Colorectal Cancer	CCLE	PDTTT	DEG_SPOP_SBC_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDTTT

Degron related mutations and impact score

Drug responses associated with SCN5A mutations

All proteins holding degron of PDTTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14524	Sodium channel protein type 5 subunit alpha	DEG_SPOP_SBC_1	628:632	PDTTT	SPOP	0.914	More...