DegronMD - Q70EL1(USP54)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1608T	TCGA-19-1389	GBM	TCGA	PPSSS	DEG_SPOP_SBC_1	1605:1609	Mutation altering degron motif	0.6005
p.K489T	TCGA-19-5956	GBM	TCGA	PSSST	DEG_SPOP_SBC_1	498:502	Mutation substituting flanking lysine	0.1944
p.I387V	TCGA-21-1077	LUSC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.3056
p.R594S	TCGA-77-8136	LUSC	TCGA	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation rewiring degron network	0.1111
p.R392Q	TCGA-A5-A2K5	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1667
p.R392Q	TCGA-BS-A0UF	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1667
p.D394Y	TCGA-AJ-A3EL	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1111
p.R506I	TCGA-AX-A2HC	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.S619R	TCGA-CG-4449	STAD	TCGA	PPSY	ITCH	621:624	Mutation rewiring degron network	0.2778
p.Y371H	TCGA-CG-5728	STAD	TCGA	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.0833
p.F628L	TCGA-CR-7389	HNSC	TCGA	PPSY	ITCH	621:624	Mutation rewiring degron network	0.2222
p.P1597H	TCGA-D3-A2JK	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	1605:1609	Mutation rewiring degron network	0.1111
p.S499F	TCGA-DA-A960	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6871
p.S372I	TCGA-E6-A1LZ	UCEC	TCGA	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1111
p.N377D	DO48566	BLCA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.25
p.E509Q	DO219024	BLCA	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation substituting flanking lysine	0.25
p.R600M	DO223732	CESC	ICGC	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation rewiring degron network	0.2778
p.P370T	DO228926	LICA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.0556
p.P390H	DO228948	LICA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.2222
p.D388E	DO229019	LICA	ICGC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation blocking phosphorylation signal	0.7222
p.A599D	DO229025	LICA	ICGC	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation rewiring degron network	0.25
p.L504I	DO229025	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2778
p.R492P	DO23556	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.L497R	DO231057	LUSC	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.R507Q	DO36556	READ	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.R507Q	DO219773	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.R507Q	DO41235	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.H624Y	DO37819	SKCM	ICGC	PPSY	ITCH	621:624	Mutation altering degron motif	0.7229
p.P502S	DO37406	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6752
p.S510P	DO48020	STAD	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.R492Q	DO40801	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.R627H	DO42384	UCEC	ICGC	PPSY	ITCH	621:624	Mutation substituting flanking lysine	0.3611
p.Q605H	DO42280	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation altering degron motif	0.7582
p.G384S	DO41644	UCEC	ICGC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation altering degron motif	0.6993
p.G620E	DO42592	UCEC	ICGC	PPSY	ITCH	621:624	Mutation blocking ubiquitination signal	0.75
p.R608Q	DO41331	UCEC	ICGC	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation rewiring degron network	0.3056
p.S501T	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6005
p.S501T	ACH-000226	Lymphoma	CCLE	PSSST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6005
p.S501T	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.6005
p.L602V	SIDM01062	Breast Carcinoma	GDSC	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation altering degron motif	0.5654
p.L602V	ACH-000643	Breast Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation altering degron motif	0.5654
p.L602V	HDQ-P1	breast	COSMIC	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation altering degron motif	0.5654
p.T393I	SIDM00282	Colorectal Carcinoma	GDSC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1389
p.T393I	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1389
p.T393I	CW-2	large intestine	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1389
p.K620N	SIDM00333	Endometrial Carcinoma	GDSC	PPSY	ITCH	621:624	Mutation blocking ubiquitination signal	0.75
p.K620N	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	621:624	Mutation blocking ubiquitination signal	0.75
p.K620N	MFE-319	endometrium	COSMIC	PPSY	ITCH	621:624	Mutation blocking ubiquitination signal	0.75
p.D625G	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	621:624	Mutation rewiring degron network	0.3056
p.D625G	SIDM00736	Non-Cancerous	GDSC	PPSY	ITCH	621:624	Mutation rewiring degron network	0.3056
p.D625G	ACH-000886	Lung Cancer	CCLE	PPSY	ITCH	621:624	Mutation rewiring degron network	0.3056
p.D625G	ACH-002366	Non-Cancerous	CCLE	PPSY	ITCH	621:624	Mutation rewiring degron network	0.3056
p.E384D	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation altering degron motif	0.5647
p.E384D	ACH-002275	Leukemia	CCLE	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation altering degron motif	0.5647
p.E384D	MN-60	haematopoietic and lymphoid tissue	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation altering degron motif	0.5647
p.K627T	SIDM01611	Endometrial Carcinoma	GDSC	PPSY	ITCH	621:624	Mutation substituting flanking lysine	0.3611
p.K627T	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	621:624	Mutation substituting flanking lysine	0.3611
p.D592E	ACH-001201	Brain Cancer	CCLE	LSPFSE	LIG_APCC_ABBA_1	602:607	Mutation rewiring degron network	0.0556
p.R492H	SNU-1040	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.P375S	SW48	large intestine	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.1944
p.I390T	MFE-319	endometrium	COSMIC	DSGREPS	DEG_SCF_TRCP1_1	380:386	Mutation rewiring degron network	0.2222
p.S497C	NCI-H2347	lung	COSMIC	PSSST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP54

UniProt ID: Q70EL1

Entrez ID: 159195

Protein name: Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP54 in