DegronMD

Uniprot ID: Q70EL1

Source protein: Inactive ubiquitin carboxyl-terminal hydrolase 54

Source gene: USP54

Class: ITCH

Location: 621:624

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9957

ASA_SCORE: 83.65

COIL: 0.8533

CONS_SCORE: 0.4859

DSS_SCORE: 0.6508

HELIX: 0.0433

FCONS_SCORE: 1.1057

RIG_SCORE: 0.6558

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S619R	TCGA-CG-4449	STAD	TCGA	PPSY	ITCH	0.2778
p.F628L	TCGA-CR-7389	HNSC	TCGA	PPSY	ITCH	0.2222
p.H624Y	DO37819	SKCM	ICGC	PPSY	ITCH	0.7229
p.R627H	DO42384	UCEC	ICGC	PPSY	ITCH	0.3611
p.G620E	DO42592	UCEC	ICGC	PPSY	ITCH	0.75
p.K620N	SIDM00333	Endometrial Carcinoma	GDSC	PPSY	ITCH	0.75
p.K620N	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	0.75
p.K620N	MFE-319	endometrium	COSMIC	PPSY	ITCH	0.75
p.D625G	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	0.3056
p.D625G	SIDM00736	Non-Cancerous	GDSC	PPSY	ITCH	0.3056
p.D625G	ACH-000886	Lung Cancer	CCLE	PPSY	ITCH	0.3056
p.D625G	ACH-002366	Non-Cancerous	CCLE	PPSY	ITCH	0.3056
p.K627T	SIDM01611	Endometrial Carcinoma	GDSC	PPSY	ITCH	0.3611
p.K627T	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	0.3611

Drug responses associated with USP54 mutations

All proteins holding degron of PPSY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NL88	Protein shisa-7	ITCH	305:308	PPSY	ITCH,NEDD4	0.6032	More...
A7KAX9	Rho GTPase-activating protein 32	ITCH	1213:1216	PPSY	ITCH,NEDD4	0.9985	More...
O15047	Histone-lysine N-methyltransferase SETD1A	ITCH	406:409	PPSY	ITCH,NEDD4	0.9978	More...
O15230	Laminin subunit alpha-5	ITCH	1697:1700	PPSY	ITCH,NEDD4	0.7918	More...
O15350	Tumor protein p73	ITCH	404:407	PPSY	ITCH,NEDD4	0.9881	More...
O43294	Transforming growth factor beta-1-induced transcript 1 protein	ITCH	35:38	PPSY	ITCH,NEDD4	0.9868	More...
O43307	Rho guanine nucleotide exchange factor 9	ITCH	465:468	PPSY	ITCH,NEDD4	0.6646	More...
O43815	Striatin	ITCH	132:135	PPSY	ITCH,NEDD4	0.5857	More...
O43861	Probable phospholipid-transporting ATPase IIB	ITCH	1139:1142	PPSY	ITCH,NEDD4	0.8321	More...
O60248	Protein SOX-15	ITCH	165:168	PPSY	ITCH,NEDD4	0.9877	More...
O60481	Zinc finger protein ZIC 3	ITCH	156:159	PPSY	ITCH,NEDD4	0.8269	More...
O60524	Ribosome quality control complex subunit NEMF	ITCH	645:648	PPSY	ITCH,NEDD4	0.855	More...
O75074	Low-density lipoprotein receptor-related protein 3	ITCH	550:553	PPSY	ITCH,NEDD4	0.6354	More...
O75110	Probable phospholipid-transporting ATPase IIA	ITCH	1039:1042	PPSY	ITCH,NEDD4	0.5408	More...
O94850	Dendrin	ITCH	200:203	PPSY	ITCH,NEDD4	0.8751	More...
O94850	Dendrin	ITCH	230:233	PPSY	ITCH,NEDD4	0.9726	More...
P09848	Lactase/phlorizin hydrolase	ITCH	1223:1226	PPSY	ITCH,NEDD4	0.5783	More...
P10253	Lysosomal alpha-glucosidase	ITCH	130:133	PPSY	ITCH,NEDD4	0.5406	More...
P11137	Microtubule-associated protein 2	ITCH	1606:1609	PPSY	ITCH,NEDD4	0.9964	More...
P11161	E3 SUMO-protein ligase EGR2	ITCH	205:208	PPSY	ITCH,NEDD4	0.9358	More...
P13611	Versican core protein	ITCH	53:56	PPSY	ITCH,NEDD4	0.9339	More...
P19235	Erythropoietin receptor	ITCH	501:504	PPSY	ITCH,NEDD4	0.9994	More...
P35498	Sodium channel protein type 1 subunit alpha	ITCH	1983:1986	PPSY	ITCH,NEDD4	0.9878	More...
P35658	Nuclear pore complex protein Nup214	ITCH	499:502	PPSY	ITCH,NEDD4	0.9977	More...
P38159	RNA-binding motif protein, X chromosome	ITCH	301:304	PPSY	ITCH,NEDD4	0.954	More...
P45880	Voltage-dependent anion-selective channel protein 2	ITCH	15:18	PPSY	ITCH,NEDD4	0.8348	More...
P49750	YLP motif-containing protein 1	ITCH	171:174	PPSY	ITCH,NEDD4	0.9883	More...
P53990	IST1 homolog	ITCH	277:280	PPSY	ITCH,NEDD4	0.9994	More...
Q01844	RNA-binding protein EWS	ITCH	187:190	PPSY	ITCH,NEDD4	0.9677	More...
Q01954	Zinc finger protein basonuclin-1	ITCH	453:456	PPSY	ITCH,NEDD4	0.9714	More...
Q13435	Splicing factor 3B subunit 2	ITCH	642:645	PPSY	ITCH,NEDD4	0.915	More...
Q13887	Krueppel-like factor 5	ITCH	325:328	PPSY	ITCH,NEDD4	0.9936	More...
Q14511	Enhancer of filamentation 1	ITCH	109:112	PPSY	ITCH,NEDD4	0.9998	More...
Q14524	Sodium channel protein type 5 subunit alpha	ITCH	1974:1977	PPSY	ITCH,NEDD4	0.9843	More...
Q14642	Inositol polyphosphate-5-phosphatase A	ITCH	324:327	PPSY	ITCH,NEDD4	0.8817	More...
Q14934	Nuclear factor of activated T-cells, cytoplasmic 4	ITCH	755:758	PPSY	ITCH,NEDD4	0.9664	More...
Q15858	Sodium channel protein type 9 subunit alpha	ITCH	1955:1958	PPSY	ITCH,NEDD4	0.9978	More...
Q16825	Tyrosine-protein phosphatase non-receptor type 21	ITCH	442:445	PPSY	ITCH,NEDD4	0.9648	More...
Q53EP0	Fibronectin type III domain-containing protein 3B	ITCH	110:113	PPSY	ITCH,NEDD4	0.9629	More...
Q5HY92	Fidgetin	ITCH	401:404	PPSY	ITCH,NEDD4	0.9941	More...
Q5VY43	Platelet endothelial aggregation receptor 1	ITCH	810:813	PPSY	ITCH,NEDD4	0.9866	More...
Q6NW40	Repulsive guidance molecule B	ITCH	157:160	PPSY	ITCH,NEDD4	0.9885	More...
Q6NXG1	Epithelial splicing regulatory protein 1	ITCH	554:557	PPSY	ITCH,NEDD4	0.6605	More...
Q6P6C2	RNA demethylase ALKBH5	ITCH	303:306	PPSY	ITCH,NEDD4	0.9987	More...
Q6PI77	Protein BHLHb9	ITCH	243:246	PPSY	ITCH,NEDD4	0.7311	More...
Q6ZSJ9	Protein shisa-6	ITCH	297:300	PPSY	ITCH,NEDD4	0.999	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	ITCH	621:624	PPSY	ITCH,NEDD4	0.9957	More...
Q7Z429	Protein lifeguard 1	ITCH	138:141	PPSY	ITCH,NEDD4	0.993	More...
Q7Z5R6	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	ITCH	587:590	PPSY	ITCH,NEDD4	0.737	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	ITCH	156:159	PPSY	ITCH,NEDD4	0.9269	More...
Q86SU0	Immunoglobulin-like domain-containing receptor 1	ITCH	509:512	PPSY	ITCH,NEDD4	0.9993	More...
Q86YD5	Low-density lipoprotein receptor class A domain-containing protein 3	ITCH	256:259	PPSY	ITCH,NEDD4	0.9739	More...
Q8IX07	Zinc finger protein ZFPM1	ITCH	949:952	PPSY	ITCH,NEDD4	0.8854	More...
Q8IZQ8	Myocardin	ITCH	720:723	PPSY	ITCH,NEDD4	0.9873	More...
Q8N114	Protein shisa-5	ITCH	166:169	PPSY	ITCH,NEDD4	0.9067	More...
Q8N2M8	CLK4-associating serine/arginine rich protein	ITCH	286:289	PPSY	ITCH,NEDD4	0.9968	More...
Q8N3V7	Synaptopodin	ITCH	581:584	PPSY	ITCH,NEDD4	0.9844	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	ITCH	181:184	PPSY	ITCH,NEDD4	0.9911	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	ITCH	337:340	PPSY	ITCH,NEDD4	0.9655	More...
Q8N5I2	Arrestin domain-containing protein 1	ITCH	415:418	PPSY	ITCH,NEDD4	0.9903	More...
Q8N6P7	Interleukin-22 receptor subunit alpha-1	ITCH	361:364	PPSY	ITCH,NEDD4	0.9931	More...
Q8N6P7	Interleukin-22 receptor subunit alpha-1	ITCH	400:403	PPSY	ITCH,NEDD4	0.9924	More...
Q8TB68	Proline-rich protein 7	ITCH	198:201	PPSY	ITCH,NEDD4	0.9815	More...
Q92692	Nectin-2	ITCH	403:406	PPSY	ITCH,NEDD4	0.9845	More...
Q92738	USP6 N-terminal-like protein	ITCH	629:632	PPSY	ITCH,NEDD4	0.9904	More...
Q92994	Transcription factor IIIB 90 kDa subunit	ITCH	291:294	PPSY	ITCH,NEDD4	0.615	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	ITCH	1965:1968	PPSY	ITCH,NEDD4	0.9035	More...
Q96B67	Arrestin domain-containing protein 3	ITCH	346:349	PPSY	ITCH,NEDD4	0.77	More...
Q96BY9	Store-operated calcium entry-associated regulatory factor	ITCH	296:299	PPSY	ITCH,NEDD4	0.9426	More...
Q96EP5	DAZ-associated protein 1	ITCH	370:373	PPSY	ITCH,NEDD4	0.9278	More...
Q96J65	ATP-binding cassette sub-family C member 12	ITCH	420:423	PPSY	ITCH,NEDD4	0.6228	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	ITCH	459:462	PPSY	ITCH,NEDD4	0.9751	More...
Q96PN7	Transcriptional-regulating factor 1	ITCH	348:351	PPSY	ITCH,NEDD4	0.9574	More...
Q96PN7	Transcriptional-regulating factor 1	ITCH	666:669	PPSY	ITCH,NEDD4	0.9486	More...
Q99250	Sodium channel protein type 2 subunit alpha	ITCH	1972:1975	PPSY	ITCH,NEDD4	0.8407	More...
Q99715	Collagen alpha-1	ITCH	2574:2577	PPSY	ITCH,NEDD4	0.6822	More...
Q99732	Lipopolysaccharide-induced tumor necrosis factor-alpha factor	ITCH	20:23	PPSY	ITCH,NEDD4	0.999	More...
Q99732	Lipopolysaccharide-induced tumor necrosis factor-alpha factor	ITCH	58:61	PPSY	ITCH,NEDD4	0.9424	More...
Q99973	Telomerase protein component 1	ITCH	981:984	PPSY	ITCH,NEDD4	0.7526	More...
Q9BQQ3	Golgi reassembly-stacking protein 1	ITCH	206:209	PPSY	ITCH,NEDD4	0.9258	More...
Q9BT67	NEDD4 family-interacting protein 1	ITCH	64:67	PPSY	ITCH,NEDD4	0.996	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	714:717	PPSY	ITCH,NEDD4	0.9896	More...
Q9BWQ8	Protein lifeguard 2	ITCH	35:38	PPSY	ITCH,NEDD4	0.9987	More...
Q9C0H2	Protein tweety homolog 3	ITCH	498:501	PPSY	ITCH,NEDD4	0.9991	More...
Q9C0H9	SRC kinase signaling inhibitor 1	ITCH	337:340	PPSY	ITCH,NEDD4	0.8002	More...
Q9H5I5	Piezo-type mechanosensitive ion channel component 2	ITCH	1828:1831	PPSY	ITCH,NEDD4	0.9755	More...
Q9H7D0	Dedicator of cytokinesis protein 5	ITCH	1438:1441	PPSY	ITCH,NEDD4	0.5355	More...
Q9HCB6	Spondin-1	ITCH	86:89	PPSY	ITCH,NEDD4	0.9801	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	ITCH	1423:1426	PPSY	ITCH,NEDD4	0.5865	More...
Q9NRM1	Enamelin	ITCH	853:856	PPSY	ITCH,NEDD4	0.9682	More...
Q9NT22	EMILIN-3	ITCH	160:163	PPSY	ITCH,NEDD4	0.9466	More...
Q9NY46	Sodium channel protein type 3 subunit alpha	ITCH	1967:1970	PPSY	ITCH,NEDD4	0.9911	More...
Q9P2U7	Vesicular glutamate transporter 1	ITCH	538:541	PPSY	ITCH,NEDD4	0.6759	More...
Q9P2Y5	UV radiation resistance-associated gene protein	ITCH	520:523	PPSY	ITCH,NEDD4	0.9988	More...
Q9UBP4	Dickkopf-related protein 3	ITCH	91:94	PPSY	ITCH,NEDD4	0.9656	More...
Q9ULQ0	Striatin-interacting protein 2	ITCH	319:322	PPSY	ITCH,NEDD4	0.9966	More...
Q9UQL6	Histone deacetylase 5	ITCH	235:238	PPSY	ITCH,NEDD4	0.9725	More...
Q9Y2V3	Retinal homeobox protein Rx	ITCH	300:303	PPSY	ITCH,NEDD4	0.999	More...
Q9Y3R5	Protein dopey-2	ITCH	542:545	PPSY	ITCH,NEDD4	0.9524	More...
Q9Y448	Small kinetochore-associated protein	ITCH	28:31	PPSY	ITCH,NEDD4	0.651	More...
Q9Y5R6	Doublesex- and mab-3-related transcription factor 1	ITCH	296:299	PPSY	ITCH,NEDD4	0.7856	More...
Q9Y5Y9	Sodium channel protein type 10 subunit alpha	ITCH	1918:1921	PPSY	ITCH,NEDD4	0.9993	More...
Q9Y6C5	Protein patched homolog 2	ITCH	11:14	PPSY	ITCH,NEDD4	0.5441	More...
Q9Y6Y8	SEC23-interacting protein	ITCH	164:167	PPSY	ITCH,NEDD4	0.9969	More...
P81408	Protein FAM189B	ITCH	284:287	PPSY	ITCH,NEDD4	0.9801	More...
Q12765	Secernin-1	ITCH	5:8	PPSY	ITCH,NEDD4	0.9614	More...
Q2T9K0	Transmembrane protein 44	ITCH	410:413	PPSY	ITCH,NEDD4	0.9989	More...
Q8N0U2	Transmembrane protein 61	ITCH	174:177	PPSY	ITCH,NEDD4	0.812	More...
Q8N103	T-cell activation Rho GTPase-activating protein	ITCH	593:596	PPSY	ITCH,NEDD4	0.9889	More...
Q96GY0	Zinc finger C2HC domain-containing protein 1A	ITCH	112:115	PPSY	ITCH,NEDD4	0.9554	More...
Q9BZD7	Transmembrane gamma-carboxyglutamic acid protein 3	ITCH	191:194	PPSY	ITCH,NEDD4	0.9237	More...
Q9P206	Uncharacterized protein KIAA1522	ITCH	675:678	PPSY	ITCH,NEDD4	0.9841	More...
Q9P266	Junctional protein associated with coronary artery disease	ITCH	295:298	PPSY	ITCH,NEDD4	0.9799	More...
Q9P266	Junctional protein associated with coronary artery disease	ITCH	343:346	PPSY	ITCH,NEDD4	0.9949	More...
A6NKD9	Coiled-coil domain-containing protein 85C	ITCH	316:319	PPSY	ITCH,NEDD4	0.9875	More...
O75526	RNA-binding motif protein, X-linked-like-2	ITCH	299:302	PPSY	ITCH,NEDD4	0.9905	More...
P78312	Protein FAM193A	ITCH	395:398	PPSY	ITCH,NEDD4	0.9956	More...
Q15884	Protein FAM189A2	ITCH	148:151	PPSY	ITCH,NEDD4	0.7961	More...
Q8IZM8	Zinc finger protein 654	ITCH	1052:1055	PPSY	ITCH,NEDD4	0.9756	More...
Q8WVE6	Transmembrane protein 171	ITCH	251:254	PPSY	ITCH,NEDD4	0.7173	More...
Q96E39	RNA binding motif protein, X-linked-like-1	ITCH	301:304	PPSY	ITCH,NEDD4	0.9917	More...
Q96PG2	Membrane-spanning 4-domains subfamily A member 10	ITCH	223:226	PPSY	ITCH,NEDD4	0.8864	More...
Q9BY19	Membrane-spanning 4-domains subfamily A member 8	ITCH	239:242	PPSY	ITCH,NEDD4	0.8237	More...
Q9H3Y0	Peptidase inhibitor R3HDML	ITCH	229:232	PPSY	ITCH,NEDD4	0.8178	More...
Q9UPR6	Zinc finger RNA-binding protein 2	ITCH	188:191	PPSY	ITCH,NEDD4	0.7633	More...
Q8N6L7	Transmembrane protein 252	ITCH	144:147	PPSY	ITCH,NEDD4	0.9986	More...
Q8NDY8	Transmembrane protein 52	ITCH	154:157	PPSY	ITCH,NEDD4	0.9237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSY

Degron related mutations and impact score

Drug responses associated with USP54 mutations

All proteins holding degron of PPSY