DegronMD - Q9BWQ8(FAIM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P32T	TCGA-19-5956	GBM	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7031
p.P32T	DO13863	GBM	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7031
p.G83R	TCGA-4W-AA9R	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0833
p.G83R	TCGA-B5-A3FC	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0833
p.S72C	TCGA-50-5946	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7541
p.K26N	TCGA-66-2727	LUSC	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.5806
p.E45Q	TCGA-91-6836	LUAD	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1389
p.E45Q	DO23854	LUAD	ICGC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1389
p.S71C	TCGA-AA-3713	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.643
p.E39D	TCGA-AP-A0LM	UCEC	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.1944
p.E39D	TCGA-AP-A0LM	UCEC	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.3056
p.G79S	TCGA-AP-A1DM	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1944
p.G79S	SIDM01199	Hepatocellular Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1944
p.G79S	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1944
p.G79S	TE-8	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1944
p.G79S	SNU-423	liver	COSMIC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1944
p.E45K	TCGA-D9-A1JW	SKCM	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1389
p.E45K	DO37786	SKCM	ICGC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1389
p.S75R	TCGA-DX-A6YT	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.3056
p.P36H	TCGA-EE-A3AA	SKCM	TCGA	PPSY	ITCH	35:38	Mutation altering degron motif	0.7694
p.P36H	DO37571	SKCM	ICGC	PPSY	ITCH	35:38	Mutation altering degron motif	0.7694
p.T15I	TCGA-EE-A3AG	SKCM	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.0833
p.T15I	DO37471	SKCM	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.0833
p.E24G	TCGA-EO-A3B0	UCEC	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7199
p.E24G	DO219773	UCEC	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7199
p.G23D	TCGA-EY-A215	UCEC	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.3056
p.G23D	DO42665	UCEC	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.3056
p.E40K	TCGA-FW-A3R5	SKCM	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.1667
p.E40K	TCGA-FW-A3R5	SKCM	TCGA	PPSY	ITCH	35:38	Mutation rewiring degron network	0.2778
p.E40K	DO37406	SKCM	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.1667
p.E40K	DO37406	SKCM	ICGC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.2778
p.S33L	TCGA-PE-A5DE	BRCA	TCGA	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.8778
p.S33L	DO225334	BRCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.8778
p.S33L	DO219643	BRCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.8778
p.T42N	DO224763	BRCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation blocking phosphorylation signal	0.5556
p.T42N	DO224763	BRCA	ICGC	PPSY	ITCH	35:38	Mutation blocking phosphorylation signal	0.6667
p.S25C	DO8400	COAD	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7541
p.E24A	DO233634	GACA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7701
p.G37R	DO219107	GBM	ICGC	PPSY	ITCH	35:38	Mutation altering degron motif	0.7568
p.G37R	DO41871	UCEC	ICGC	PPSY	ITCH	35:38	Mutation altering degron motif	0.7568
p.D23E	DO228976	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.3056
p.Q18K	DO228976	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.1667
p.L41I	DO229018	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.1389
p.L41I	DO229018	LICA	ICGC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.25
p.P83T	DO229015	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0833
p.S27R	DO229006	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7427
p.V84F	DO25629	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.S26C	DO24556	LUAD	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7541
p.S29R	DO220007	SARC	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.7427
p.G46R	DO229453	SKCA	ICGC	PPSY	ITCH	35:38	Mutation rewiring degron network	0.1111
p.T79A	DO229268	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1944
p.A20S	DO229213	THCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.2222
p.G33S	DO43106	UCEC	ICGC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.6993
p.G33S	SNU-423	liver	COSMIC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.6993
p.G33S	TE-8	oesophagus	COSMIC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation altering degron motif	0.6993
p.S64I	ACH-000211	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1667
p.S64I	Daoy	central nervous system	COSMIC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1667
p.S18I	Daoy	central nervous system	COSMIC	EKKEAPAVPSA	DEG_COP1_1	24:34	Mutation rewiring degron network	0.1667
p.I63V	CAKI-1	kidney	COSMIC	PSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1389

Kaplan plot for FAIM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAIM2

UniProt ID: Q9BWQ8

Entrez ID: 23017

Protein name: Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAIM2 in