DegronMD

Uniprot ID: Q9BWQ8

Source protein: Protein lifeguard 2

Source gene: FAIM2

Class: DEG_COP1_1

Location: 24:34

E3 ligase: COP1

DEGRON score: 0.9929

ASA_SCORE: 82.4273

COIL: 0.9155

CONS_SCORE: 0.2714

DSS_SCORE: 0.715

HELIX: 0.0385

FCONS_SCORE: 0.9968

RIG_SCORE: 0.6174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P32T	TCGA-19-5956	GBM	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.7031
p.P32T	DO13863	GBM	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.7031
p.K26N	TCGA-66-2727	LUSC	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.5806
p.E39D	TCGA-AP-A0LM	UCEC	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.1944
p.T15I	TCGA-EE-A3AG	SKCM	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.0833
p.T15I	DO37471	SKCM	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.0833
p.E24G	TCGA-EO-A3B0	UCEC	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.7199
p.E24G	DO219773	UCEC	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.7199
p.G23D	TCGA-EY-A215	UCEC	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.3056
p.G23D	DO42665	UCEC	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.3056
p.E40K	TCGA-FW-A3R5	SKCM	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.1667
p.E40K	DO37406	SKCM	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.1667
p.S33L	TCGA-PE-A5DE	BRCA	TCGA	EKKEAPAVPSA	DEG_COP1_1	0.8778
p.S33L	DO225334	BRCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.8778
p.S33L	DO219643	BRCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.8778
p.T42N	DO224763	BRCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.5556
p.S25C	DO8400	COAD	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.7541
p.E24A	DO233634	GACA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.7701
p.D23E	DO228976	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.3056
p.Q18K	DO228976	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.1667
p.L41I	DO229018	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.1389
p.S27R	DO229006	LICA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.7427
p.S26C	DO24556	LUAD	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.7541
p.S29R	DO220007	SARC	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.7427
p.A20S	DO229213	THCA	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.2222
p.G33S	DO43106	UCEC	ICGC	EKKEAPAVPSA	DEG_COP1_1	0.6993
p.G33S	SNU-423	liver	COSMIC	EKKEAPAVPSA	DEG_COP1_1	0.6993
p.G33S	TE-8	oesophagus	COSMIC	EKKEAPAVPSA	DEG_COP1_1	0.6993
p.S18I	Daoy	central_nervous_system	COSMIC	EKKEAPAVPSA	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWQ8	Protein lifeguard 2	DEG_COP1_1	24:34	EKKEAPAVPSA	COP1	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EKKEAPAVPSA

Degron related mutations and impact score

Drug responses associated with FAIM2 mutations

All proteins holding degron of EKKEAPAVPSA