DegronMD - Q99973(TEP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1682A	TCGA-06-5413	GBM	TCGA	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.2222
p.A1681P	TCGA-25-2401	OV	TCGA	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.25
p.L901R	TCGA-BR-4292	STAD	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.8428
p.P887H	TCGA-CV-5442	HNSC	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.3056
p.P887H	DO14678	HNSC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.3056
p.S975F	TCGA-D3-A2JO	SKCM	TCGA	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1667
p.S975F	TCGA-L9-A8F4	LUAD	TCGA	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1667
p.P887L	TCGA-D3-A3C7	SKCM	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.3056
p.P887L	DO47569	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.3056
p.L888F	TCGA-D3-A8GM	SKCM	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.6981
p.L888F	DO50288	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.6981
p.E882D	TCGA-E6-A1LX	UCEC	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.1667
p.E882D	DO41020	UCEC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.1667
p.E432D	TCGA-E6-A1LX	UCEC	TCGA	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.1944
p.E432D	DO41020	UCEC	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.1944
p.T1680I	TCGA-EE-A2MS	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.2778
p.S1668N	TCGA-EE-A3J5	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.1667
p.Q455H	TCGA-ER-A19B	SKCM	TCGA	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.0556
p.Q455H	DO47491	SKCM	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.0556
p.K443E	TCGA-FI-A2D5	UCEC	TCGA	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.591
p.K443E	DO41331	UCEC	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.591
p.R897H	TCGA-FP-A4BE	STAD	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7133
p.L986F	TCGA-GN-A8LK	SKCM	TCGA	PPSY	ITCH	981:984	Mutation rewiring degron network	0.2778
p.L986F	SIDM00545	Melanoma	GDSC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.2778
p.L986F	Mewo	skin	COSMIC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.2778
p.P890S	TCGA-HC-7820	PRAD	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.6752
p.P890S	DO49811	PRAD	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.6752
p.G973C	DO51949	BLCA	ICGC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.G973C	DO233116	GACA	ICGC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.G973C	ACH-000975	Lung Cancer	CCLE	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.G973A	DO51907	BLCA	ICGC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1111
p.R447Q	DO223425	CLLE	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.2778
p.M902I	DO230659	LAML	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.3056
p.M902I	DO231140	LAML	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.3056
p.R910S	DO228929	LICA	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.0833
p.L444M	DO228948	LICA	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.5999
p.H885N	DO229018	LICA	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.25
p.G972E	DO50970	LICA	ICGC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.0833
p.Y980C	DO52254	LIHC	ICGC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.3056
p.R878Q	DO23436	LINC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.0556
p.E898K	DO231072	LUSC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7022
p.E898K	ACH-000439	Leukemia	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7022
p.E898K	ACH-002041	Thyroid Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7022
p.E898K	ACH-002274	Leukemia	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7022
p.E898K	ME-1	haematopoietic and lymphoid tissue	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7022
p.E898K	MLMA	haematopoietic and lymphoid tissue	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7022
p.G893E	DO37547	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7199
p.G893R	DO37547	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7568
p.R907L	DO37595	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.1667
p.G1683W	DO37431	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.1944
p.R1682S	DO47469	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.2222
p.L878F	DO51259	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.0556
p.L878F	ACH-000987	Skin Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.0556
p.L878F	Mewo	skin	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.0556
p.V901A	DO38683	STAD	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.6936
p.G1673V	DO47837	STAD	ICGC	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.3056
p.R976C	SIDM02065	Colorectal Carcinoma	GDSC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1944
p.R976C	SIDM00628	Breast Carcinoma	GDSC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1944
p.R878W	SIDM01293	Colorectal Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.0556
p.K434N	SIDM00630	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00969	Ovarian Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM01002	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00654	Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00210	Ovarian Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00529	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00650	Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM01133	Other Solid Cancers	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM01681	Non-Cancerous	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM00721	Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.K434N	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation blocking ubiquitination signal	0.6944
p.P437L	SIDM00120	Prostate Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.6471
p.P437L	DU-145	prostate	COSMIC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.6471
p.R908Q	SIDM00193	Colorectal Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.1389
p.R908Q	SNU-81	large intestine	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.1389
p.G427D	SIDM00874	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.0556
p.G427D	SIDM01247	Burkitt's Lymphoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.0556
p.G427D	SIDM01056	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.0556
p.G427D	SIDM00873	Non-Cancerous	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.0556
p.R976H	SIDM00214	Colorectal Carcinoma	GDSC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1944
p.R976H	SNU-407	large intestine	COSMIC	PPSY	ITCH	981:984	Mutation rewiring degron network	0.1944
p.P890L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7582
p.P890L	KYSE-270	oesophagus	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.7582
p.P982S	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	981:984	Mutation altering degron motif	0.6752
p.P982S	IA-LM	lung	COSMIC	PPSY	ITCH	981:984	Mutation altering degron motif	0.6752
p.M910T	SIDM01619	Endometrial Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation rewiring degron network	0.0833
p.R894H	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.8244
p.R894H	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.8244
p.R894H	HCT-15	large intestine	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	888:901	Mutation altering degron motif	0.8244
p.V1669M	ACH-001369	Ovarian Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.1944
p.A445V	SNU-175	large intestine	COSMIC	PRFTLKKLV	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.6936
p.S1669P	MFE-319	endometrium	COSMIC	AVSSS	DEG_SPOP_SBC_1	1674:1678	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TEP1

UniProt ID: Q99973

Entrez ID: 7011

Protein name: Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TEP1 in