DegronMD

Uniprot ID: Q99973

Source protein: Telomerase protein component 1

Source gene: TEP1

Class: DEG_ODPH_VHL_1

Location: 888:901

E3 ligase: VHL

DEGRON score: 0.6441

ASA_SCORE: 61.3286

COIL: 0.5574

CONS_SCORE: 0.5142

DSS_SCORE: 0.3497

HELIX: 0.0138

FCONS_SCORE: 0.9612

RIG_SCORE: 0.7585

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L901R	TCGA-BR-4292	STAD	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.8428
p.P887H	TCGA-CV-5442	HNSC	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.3056
p.P887H	DO14678	HNSC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.3056
p.P887L	TCGA-D3-A3C7	SKCM	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.3056
p.P887L	DO47569	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.3056
p.L888F	TCGA-D3-A8GM	SKCM	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.6981
p.L888F	DO50288	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.6981
p.E882D	TCGA-E6-A1LX	UCEC	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.1667
p.E882D	DO41020	UCEC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.1667
p.R897H	TCGA-FP-A4BE	STAD	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7133
p.P890S	TCGA-HC-7820	PRAD	TCGA	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.6752
p.P890S	DO49811	PRAD	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.6752
p.M902I	DO230659	LAML	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.3056
p.M902I	DO231140	LAML	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.3056
p.R910S	DO228929	LICA	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.0833
p.H885N	DO229018	LICA	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.25
p.R878Q	DO23436	LINC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.0556
p.E898K	DO231072	LUSC	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7022
p.E898K	ACH-000439	Leukemia	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7022
p.E898K	ACH-002041	Thyroid Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7022
p.E898K	ACH-002274	Leukemia	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7022
p.E898K	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7022
p.E898K	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7022
p.G893E	DO37547	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7199
p.G893R	DO37547	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7568
p.R907L	DO37595	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.1667
p.L878F	DO51259	SKCM	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.0556
p.L878F	ACH-000987	Skin Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.0556
p.L878F	Mewo	skin	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.0556
p.V901A	DO38683	STAD	ICGC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.6936
p.R878W	SIDM01293	Colorectal Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.0556
p.R908Q	SIDM00193	Colorectal Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.1389
p.R908Q	SNU-81	large_intestine	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.1389
p.P890L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7582
p.P890L	KYSE-270	oesophagus	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.7582
p.M910T	SIDM01619	Endometrial Carcinoma	GDSC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.0833
p.R894H	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.8244
p.R894H	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.8244
p.R894H	HCT-15	large_intestine	COSMIC	LAPVSQQGWRSIRL	DEG_ODPH_VHL_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPVSQQGWRSIRL

Degron related mutations and impact score

Drug responses associated with TEP1 mutations

All proteins holding degron of LAPVSQQGWRSIRL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99973	Telomerase protein component 1	DEG_ODPH_VHL_1	888:901	LAPVSQQGWRSIRL	VHL	0.6441	More...