DegronMD

Uniprot ID: Q99973

Source protein: Telomerase protein component 1

Source gene: TEP1

Class: DEG_APCC_DBOX_1

Location: 437:445

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7984

ASA_SCORE: 69.9333

COIL: 0.4197

CONS_SCORE: 0.5585

DSS_SCORE: 0.4609

HELIX: 0.556

FCONS_SCORE: 1.1054

RIG_SCORE: 0.7971

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E432D	TCGA-E6-A1LX	UCEC	TCGA	PRFTLKKLV	DEG_APCC_DBOX_1	0.1944
p.E432D	DO41020	UCEC	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	0.1944
p.Q455H	TCGA-ER-A19B	SKCM	TCGA	PRFTLKKLV	DEG_APCC_DBOX_1	0.0556
p.Q455H	DO47491	SKCM	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	0.0556
p.K443E	TCGA-FI-A2D5	UCEC	TCGA	PRFTLKKLV	DEG_APCC_DBOX_1	0.591
p.K443E	DO41331	UCEC	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	0.591
p.R447Q	DO223425	CLLE	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	0.2778
p.L444M	DO228948	LICA	ICGC	PRFTLKKLV	DEG_APCC_DBOX_1	0.5999
p.K434N	SIDM00630	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00969	Ovarian Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM01002	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00654	Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00210	Ovarian Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00529	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00650	Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM01133	Other Solid Cancers	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM01681	Non-Cancerous	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM00721	Small Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.K434N	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6944
p.P437L	SIDM00120	Prostate Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6471
p.P437L	DU-145	prostate	COSMIC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6471
p.G427D	SIDM00874	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.0556
p.G427D	SIDM01247	Burkitt's Lymphoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.0556
p.G427D	SIDM01056	Breast Carcinoma	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.0556
p.G427D	SIDM00873	Non-Cancerous	GDSC	PRFTLKKLV	DEG_APCC_DBOX_1	0.0556
p.A445V	SNU-175	large_intestine	COSMIC	PRFTLKKLV	DEG_APCC_DBOX_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRFTLKKLV

Degron related mutations and impact score

Drug responses associated with TEP1 mutations

All proteins holding degron of PRFTLKKLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99973	Telomerase protein component 1	DEG_APCC_DBOX_1	437:445	PRFTLKKLV	APC,CDC20,FZR1	0.7984	More...