DegronMD - Q9Y5Y9(SCN10A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1927S	TCGA-94-8490	LUSC	TCGA	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.1667
p.G1927S	DO52021	LUSC	ICGC	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.1667
p.S985N	TCGA-AP-A0LM	UCEC	TCGA	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.2222
p.S985N	DO43306	UCEC	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.2222
p.P977S	TCGA-AX-A2HC	UCEC	TCGA	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.5641
p.P977S	DO222875	MELA	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.5641
p.P977S	DO219878	SKCA	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.5641
p.P977S	DO41572	UCEC	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.5641
p.S954F	TCGA-BF-A3DM	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation altering degron motif	0.7982
p.S954F	TCGA-D5-5538	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation altering degron motif	0.7982
p.S954F	DO8962	COAD	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation altering degron motif	0.7982
p.S954F	DO48667	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation altering degron motif	0.7982
p.A989T	TCGA-BR-8591	STAD	TCGA	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.1111
p.A989T	TCGA-EO-A22R	UCEC	TCGA	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.1111
p.A989T	DO47973	STAD	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.1111
p.A989T	DO42713	UCEC	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.1111
p.E959D	TCGA-E6-A1LX	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.25
p.E959D	DO41020	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.25
p.R1926K	TCGA-EB-A5FP	SKCM	TCGA	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.1944
p.R1926K	DO47362	SKCM	ICGC	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.1944
p.P1918S	TCGA-EE-A29E	SKCM	TCGA	PPSY	ITCH	1918:1921	Mutation altering degron motif	0.6752
p.P1918S	DO37831	SKCM	ICGC	PPSY	ITCH	1918:1921	Mutation altering degron motif	0.6752
p.R981K	TCGA-EE-A2GO	SKCM	TCGA	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.7237
p.R981K	DO37823	SKCM	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.7237
p.K942E	TCGA-EO-A22X	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation substituting flanking lysine	0.1667
p.K942E	DO43907	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation substituting flanking lysine	0.1667
p.K1908T	TCGA-FI-A2D5	UCEC	TCGA	PPSY	ITCH	1918:1921	Mutation substituting flanking lysine	0.1667
p.K1908T	DO41331	UCEC	ICGC	PPSY	ITCH	1918:1921	Mutation substituting flanking lysine	0.1667
p.P1919Q	TCGA-O2-A52Q	LUSC	TCGA	PPSY	ITCH	1918:1921	Mutation altering degron motif	0.7035
p.P1919Q	DO219219	LUSC	ICGC	PPSY	ITCH	1918:1921	Mutation altering degron motif	0.7035
p.S970I	TCGA-VQ-A8DT	STAD	TCGA	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.2222
p.S970I	DO51751	STAD	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.2222
p.S955N	TCGA-VS-A94Z	CESC	TCGA	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation altering degron motif	0.7069
p.S955N	DO51634	CESC	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation altering degron motif	0.7069
p.R978K	DO225367	BRCA	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.7237
p.I962V	DO229010	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.1667
p.I962V	DO229016	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.1667
p.I962V	DO229003	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.1667
p.I962V	DO229005	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.1667
p.I962V	DO228941	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.1667
p.I962V	DO231051	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.1667
p.I962V	DO231049	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.1667
p.R968G	DO233784	GACA	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.1667
p.A943S	DO23422	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.0833
p.K942N	DO23422	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation substituting flanking lysine	0.1667
p.L974I	DO230525	LUSC	ICGC	LQAPRGPR	SCF_FBXL2	974:981	Mutation altering degron motif	0.6063
p.E1910K	DO222516	MELA	ICGC	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.1111
p.D1930N	DO229456	SKCA	ICGC	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.0833
p.P991L	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.0556
p.P991L	SIDM00883	Non-Cancerous	GDSC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.0556
p.S1909Y	SIDM01047	Chronic Myelogenous Leukemia	GDSC	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.0833
p.S1909Y	ACH-000295	Leukemia	CCLE	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.0833
p.S1909Y	EM-2	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.0833
p.V948L	SIDM01073	Other Blood Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	952:956	Mutation rewiring degron network	0.2222
p.P991S	SIDM00516	Melanoma	GDSC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.0556
p.P991S	ACH-002166	Skin Cancer	CCLE	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.0556
p.P991S	MZ7-mel	skin	COSMIC	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.0556
p.F987V	ACH-001111	Lymphoma	CCLE	LQAPRGPR	SCF_FBXL2	974:981	Mutation rewiring degron network	0.1667
p.A1912S	ACH-001852	Bile Duct Cancer	CCLE	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.1667
p.S1908Y	EM-2	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	1918:1921	Mutation substituting flanking lysine	0.1667
p.V1931L	HT-29	large intestine	COSMIC	PPSY	ITCH	1918:1921	Mutation rewiring degron network	0.0556

Kaplan plot for SCN10A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN10A

UniProt ID: Q9Y5Y9

Entrez ID: 6336

Protein name: Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN10A in