DegronMD

Uniprot ID: Q9Y5Y9

Source protein: Sodium channel protein type 10 subunit alpha

Source gene: SCN10A

Class: SCF_FBXL2

Location: 974:981

E3 ligase: FBXL2

DEGRON score: 0.9986

ASA_SCORE: 77.7625

COIL: 0.8294

CONS_SCORE: 0.2997

DSS_SCORE: 0.6745

HELIX: 0.0498

FCONS_SCORE: 1.2768

RIG_SCORE: 0.5929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S985N	TCGA-AP-A0LM	UCEC	TCGA	LQAPRGPR	SCF_FBXL2	0.2222
p.S985N	DO43306	UCEC	ICGC	LQAPRGPR	SCF_FBXL2	0.2222
p.P977S	TCGA-AX-A2HC	UCEC	TCGA	LQAPRGPR	SCF_FBXL2	0.5641
p.P977S	DO222875	MELA	ICGC	LQAPRGPR	SCF_FBXL2	0.5641
p.P977S	DO219878	SKCA	ICGC	LQAPRGPR	SCF_FBXL2	0.5641
p.P977S	DO41572	UCEC	ICGC	LQAPRGPR	SCF_FBXL2	0.5641
p.A989T	TCGA-BR-8591	STAD	TCGA	LQAPRGPR	SCF_FBXL2	0.1111
p.A989T	TCGA-EO-A22R	UCEC	TCGA	LQAPRGPR	SCF_FBXL2	0.1111
p.A989T	DO47973	STAD	ICGC	LQAPRGPR	SCF_FBXL2	0.1111
p.A989T	DO42713	UCEC	ICGC	LQAPRGPR	SCF_FBXL2	0.1111
p.R981K	TCGA-EE-A2GO	SKCM	TCGA	LQAPRGPR	SCF_FBXL2	0.7237
p.R981K	DO37823	SKCM	ICGC	LQAPRGPR	SCF_FBXL2	0.7237
p.S970I	TCGA-VQ-A8DT	STAD	TCGA	LQAPRGPR	SCF_FBXL2	0.2222
p.S970I	DO51751	STAD	ICGC	LQAPRGPR	SCF_FBXL2	0.2222
p.R978K	DO225367	BRCA	ICGC	LQAPRGPR	SCF_FBXL2	0.7237
p.R968G	DO233784	GACA	ICGC	LQAPRGPR	SCF_FBXL2	0.1667
p.L974I	DO230525	LUSC	ICGC	LQAPRGPR	SCF_FBXL2	0.6063
p.P991L	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQAPRGPR	SCF_FBXL2	0.0556
p.P991L	SIDM00883	Non-Cancerous	GDSC	LQAPRGPR	SCF_FBXL2	0.0556
p.P991S	SIDM00516	Melanoma	GDSC	LQAPRGPR	SCF_FBXL2	0.0556
p.P991S	ACH-002166	Skin Cancer	CCLE	LQAPRGPR	SCF_FBXL2	0.0556
p.P991S	MZ7-mel	skin	COSMIC	LQAPRGPR	SCF_FBXL2	0.0556
p.F987V	ACH-001111	Lymphoma	CCLE	LQAPRGPR	SCF_FBXL2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5Y9	Sodium channel protein type 10 subunit alpha	SCF_FBXL2	974:981	LQAPRGPR	FBXL2	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons