DegronMD - P11161(EGR2)

FUNCTION: Sequence-specific DNA-binding transcription factor (PubMed:17717711). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance... View more >>

GO - Biological processes (BP): aorta development [GO:0035904]; brain development [GO:0007420]; brain segmentation [GO:0035284]; cellular response to organic substance [GO:0071310]; facial nerve structural organization [GO:0021612]; fat cell differentiation [GO:0045444]; gene expression [GO:0010467]; learning or memory [GO:0007611... View more >>

GO - Molecular function (MF): chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; meta... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R207W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	205:208	Mutation altering degron motif	0.8634
p.H264R	NCI-H838	lung	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.8244
p.P260A	TCGA-77-A5GH	LUSC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.7503
p.P260A	DO45452	LUSC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.7503
p.Y165H	DO36556	READ	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.7229
p.D160G	DO46493	OV	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.7198
p.P127Q	DO228948	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7035
p.P264T	DO229037	LICA	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.7031
p.P206S	TCGA-55-7727	LUAD	TCGA	PPSY	ITCH	205:208	Mutation altering degron motif	0.6752
p.P206S	DO24297	LUAD	ICGC	PPSY	ITCH	205:208	Mutation altering degron motif	0.6752
p.P260S	TCGA-CG-4442	STAD	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.6752
p.P260S	DO38380	STAD	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.6752
p.P295S	ACH-001521	Skin Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.6752
p.D162A	TCGA-AA-3949	COAD	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6682
p.D162A	DO7798	COAD	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6682
p.L265P	DO234201	ESAD	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.6471
p.L164P	SIDM00498	Colorectal Carcinoma	GDSC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6471
p.L164P	ACH-000970	Colon/Colorectal Cancer	CCLE	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6471
p.L164P	SNU-C5	large intestine	COSMIC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6471
p.P261T	DO228974	LICA	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.5919

Showing 1 to 20 of 105 entries

Previous1 2 3 4 5 6Next

Kaplan plot for EGR2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EGR2

UniProt ID: P11161

Entrez ID: 1959

Protein name: E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (AT591) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EGR2 in