DegronMD - P11161(EGR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A309T	TCGA-06-5416	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.A309T	DO10880	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.A308T	TCGA-06-5416	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.A308T	DO223157	ESCA	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.A308T	DO10880	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.A308T	DO232224	PBCA	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.A307T	TCGA-06-5416	GBM	TCGA	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1111
p.A307T	DO10880	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1111
p.P206S	TCGA-55-7727	LUAD	TCGA	PPSY	ITCH	205:208	Mutation altering degron motif	0.6752
p.P206S	DO24297	LUAD	ICGC	PPSY	ITCH	205:208	Mutation altering degron motif	0.6752
p.T153A	TCGA-66-2767	LUSC	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.1389
p.T153A	DO26713	LUSC	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.1389
p.P252T	TCGA-66-2785	LUSC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1111
p.P252T	DO26520	LUSC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1111
p.P260A	TCGA-77-A5GH	LUSC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.7503
p.P260A	DO45452	LUSC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.7503
p.D162A	TCGA-AA-3949	COAD	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6682
p.D162A	DO7798	COAD	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6682
p.P172S	TCGA-AG-A002	READ	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.25
p.P172S	DO222843	MELA	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.25
p.G179R	TCGA-AM-5820	COAD	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.0556
p.G179R	DO9082	COAD	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.0556
p.G275V	TCGA-AP-A059	UCEC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1111
p.G275V	DO41361	UCEC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1111
p.G123W	TCGA-C8-A8HQ	BRCA	TCGA	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.G123W	DO219623	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.P260S	TCGA-CG-4442	STAD	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.6752
p.P260S	DO38380	STAD	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.6752
p.A187T	TCGA-CM-5861	COAD	TCGA	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2222
p.A187T	DO7918	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2222
p.A187V	TCGA-CM-6162	COAD	TCGA	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2222
p.A187V	DO8479	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2222
p.A187V	ACH-000774	Lung Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2222
p.D160N	TCGA-D3-A1Q6	SKCM	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.5821
p.D160N	DO37450	SKCM	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.5821
p.L273M	TCGA-E6-A1LX	UCEC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1667
p.L273M	DO41020	UCEC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1667
p.L273M	SIDM00324	Neuroblastoma	GDSC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1667
p.L273M	ACH-001674	Neuroblastoma	CCLE	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1667
p.L273M	TGW	autonomic ganglia	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1667
p.D254Y	TCGA-EE-A29P	SKCM	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1667
p.D254Y	DO37916	SKCM	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1667
p.P173S	TCGA-EE-A2M5	SKCM	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.2222
p.P173S	DO37425	SKCM	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.2222
p.R257W	TCGA-EI-6882	READ	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.25
p.R257W	DO36531	READ	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.25
p.R257W	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.25
p.R257W	ACH-001738	Leukemia	CCLE	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.25
p.R257W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.25
p.P250L	TCGA-EO-A3KX	UCEC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.0556
p.P250L	DO219774	UCEC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.0556
p.A306T	TCGA-EY-A215	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.A306T	DO42665	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.A306T	SIDM00819	Kidney Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.A306T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.A306T	ACH-002189	Kidney Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.P171L	TCGA-FI-A2D5	UCEC	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.2778
p.P171L	DO41331	UCEC	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.2778
p.P141S	TCGA-FW-A3R5	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.P141S	DO37406	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.A300E	TCGA-HN-A2NL	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.A300E	DO219637	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.3056
p.S199A	TCGA-KD-A5QS	SARC	TCGA	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2222
p.S199A	TCGA-KD-A5QS	SARC	TCGA	PPSY	ITCH	205:208	Mutation rewiring degron network	0.1667
p.S199A	DO223270	SARC	ICGC	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2222
p.S199A	DO223270	SARC	ICGC	PPSY	ITCH	205:208	Mutation rewiring degron network	0.1667
p.V258A	TCGA-OR-A5LB	ACC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.2778
p.P170L	TCGA-RP-A695	SKCM	TCGA	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.3056
p.P170L	DO51270	SKCM	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.3056
p.A214V	DO222404	BTCA	ICGC	PPSY	ITCH	205:208	Mutation rewiring degron network	0.1667
p.L265P	DO234201	ESAD	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.6471
p.A305T	DO233784	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.A305T	DO51486	PACA	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1667
p.A306G	DO233882	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.T196S	DO18392	KIRC	ICGC	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.3056
p.T196S	DO18392	KIRC	ICGC	PPSY	ITCH	205:208	Mutation rewiring degron network	0.0833
p.P127Q	DO228948	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7035
p.A285D	DO228974	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0556
p.P261T	DO228974	LICA	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.5919
p.P264T	DO229037	LICA	ICGC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.7031
p.Q122K	DO229041	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.G291R	DO231124	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.2222
p.D160G	DO46493	OV	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.7198
p.S133L	DO227531	PACA	ICGC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.Y165H	DO36556	READ	ICGC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.7229
p.P172H	SIDM00683	Prostate Carcinoma	GDSC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.25
p.P172H	ACH-000977	lymph node	CCLE	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.25
p.P172H	LNCaP-Clone-FGC	prostate	COSMIC	DLDHLYSPPP	CBL_PTK	160:169	Mutation rewiring degron network	0.25
p.T215M	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSY	ITCH	205:208	Mutation rewiring degron network	0.1389
p.L164P	SIDM00498	Colorectal Carcinoma	GDSC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6471
p.L164P	ACH-000970	Colon/Colorectal Cancer	CCLE	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6471
p.L164P	SNU-C5	large intestine	COSMIC	DLDHLYSPPP	CBL_PTK	160:169	Mutation altering degron motif	0.6471
p.V136A	SIDM00217	Colorectal Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.V136A	ACH-000999	Colon/Colorectal Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.V136A	SNU-1040	large intestine	COSMIC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P252S	ACH-000017	Breast Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1111
p.T255P	ACH-000979	Prostate Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1944
p.V258M	ACH-001369	Ovarian Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.2778
p.P295S	ACH-001521	Skin Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.6752
p.P252L	ACH-002041	Thyroid Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.1111
p.L188P	FU-OV-1	ovary	COSMIC	AATTS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.25
p.H264R	NCI-H838	lung	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation altering degron motif	0.8244
p.P122H	LNCaP-Clone-FGC	prostate	COSMIC	PASTT	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.R207W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	205:208	Mutation altering degron motif	0.8634
p.R268Q	HT-115	large intestine	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	260:267	Mutation rewiring degron network	0.3056

Kaplan plot for EGR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EGR2

UniProt ID: P11161

Entrez ID: 1959

Protein name: E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (AT591) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EGR2 in