DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DLDHLYSPPP
Uniprot ID:
P11161
Source protein:
E3 SUMO-protein ligase EGR2
Source gene:
EGR2
Class:
CBL_PTK
Location:
160:169
E3 ligase:
CBL
DEGRON score:
0.9884
ASA_SCORE:
99.89
COIL:
0.92
CONS_SCORE:
0.5536
DSS_SCORE:
0.7043
HELIX:
0.0524
FCONS_SCORE:
1.0724
RIG_SCORE:
0.6405
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T153A
TCGA-66-2767
LUSC
TCGA
DLDHLYSPPP
CBL_PTK
0.1389
p.T153A
DO26713
LUSC
ICGC
DLDHLYSPPP
CBL_PTK
0.1389
p.D162A
TCGA-AA-3949
COAD
TCGA
DLDHLYSPPP
CBL_PTK
0.6682
p.D162A
DO7798
COAD
ICGC
DLDHLYSPPP
CBL_PTK
0.6682
p.P172S
TCGA-AG-A002
READ
TCGA
DLDHLYSPPP
CBL_PTK
0.25
p.P172S
DO222843
MELA
ICGC
DLDHLYSPPP
CBL_PTK
0.25
p.G179R
TCGA-AM-5820
COAD
TCGA
DLDHLYSPPP
CBL_PTK
0.0556
p.G179R
DO9082
COAD
ICGC
DLDHLYSPPP
CBL_PTK
0.0556
p.D160N
TCGA-D3-A1Q6
SKCM
TCGA
DLDHLYSPPP
CBL_PTK
0.5821
p.D160N
DO37450
SKCM
ICGC
DLDHLYSPPP
CBL_PTK
0.5821
p.P173S
TCGA-EE-A2M5
SKCM
TCGA
DLDHLYSPPP
CBL_PTK
0.2222
p.P173S
DO37425
SKCM
ICGC
DLDHLYSPPP
CBL_PTK
0.2222
p.P171L
TCGA-FI-A2D5
UCEC
TCGA
DLDHLYSPPP
CBL_PTK
0.2778
p.P171L
DO41331
UCEC
ICGC
DLDHLYSPPP
CBL_PTK
0.2778
p.P170L
TCGA-RP-A695
SKCM
TCGA
DLDHLYSPPP
CBL_PTK
0.3056
p.P170L
DO51270
SKCM
ICGC
DLDHLYSPPP
CBL_PTK
0.3056
p.D160G
DO46493
OV
ICGC
DLDHLYSPPP
CBL_PTK
0.7198
p.Y165H
DO36556
READ
ICGC
DLDHLYSPPP
CBL_PTK
0.7229
p.P172H
SIDM00683
Prostate Carcinoma
GDSC
DLDHLYSPPP
CBL_PTK
0.25
p.P172H
ACH-000977
lymph_node
CCLE
DLDHLYSPPP
CBL_PTK
0.25
p.P172H
LNCaP-Clone-FGC
prostate
COSMIC
DLDHLYSPPP
CBL_PTK
0.25
p.L164P
SIDM00498
Colorectal Carcinoma
GDSC
DLDHLYSPPP
CBL_PTK
0.6471
p.L164P
ACH-000970
Colon/Colorectal Cancer
CCLE
DLDHLYSPPP
CBL_PTK
0.6471
p.L164P
SNU-C5
large_intestine
COSMIC
DLDHLYSPPP
CBL_PTK
0.6471
Drug responses associated with EGR2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DLDHLYSPPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P11161
E3 SUMO-protein ligase EGR2
CBL_PTK
160:169
DLDHLYSPPP
CBL
0.9884
More...