DegronMD

Uniprot ID: P11161

Source protein: E3 SUMO-protein ligase EGR2

Source gene: EGR2

Class: DEG_SCF_FBW7_1

Location: 260:267

E3 ligase: FBXW7

DEGRON score: 0.9849

ASA_SCORE: 68.025

COIL: 0.6999

CONS_SCORE: 0.5864

DSS_SCORE: 0.5179

HELIX: 0.239

FCONS_SCORE: 1.0885

RIG_SCORE: 0.7559

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P252T	TCGA-66-2785	LUSC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.1111
p.P252T	DO26520	LUSC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.1111
p.P260A	TCGA-77-A5GH	LUSC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.7503
p.P260A	DO45452	LUSC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.7503
p.G275V	TCGA-AP-A059	UCEC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.1111
p.G275V	DO41361	UCEC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.1111
p.P260S	TCGA-CG-4442	STAD	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.6752
p.P260S	DO38380	STAD	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.6752
p.L273M	TCGA-E6-A1LX	UCEC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.1667
p.L273M	DO41020	UCEC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.1667
p.L273M	SIDM00324	Neuroblastoma	GDSC	PPLTPLST	DEG_SCF_FBW7_1	0.1667
p.L273M	ACH-001674	Neuroblastoma	CCLE	PPLTPLST	DEG_SCF_FBW7_1	0.1667
p.L273M	TGW	autonomic_ganglia	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	0.1667
p.D254Y	TCGA-EE-A29P	SKCM	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.1667
p.D254Y	DO37916	SKCM	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.1667
p.R257W	TCGA-EI-6882	READ	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.25
p.R257W	DO36531	READ	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.25
p.R257W	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PPLTPLST	DEG_SCF_FBW7_1	0.25
p.R257W	ACH-001738	Leukemia	CCLE	PPLTPLST	DEG_SCF_FBW7_1	0.25
p.R257W	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	0.25
p.P250L	TCGA-EO-A3KX	UCEC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.0556
p.P250L	DO219774	UCEC	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.0556
p.V258A	TCGA-OR-A5LB	ACC	TCGA	PPLTPLST	DEG_SCF_FBW7_1	0.2778
p.L265P	DO234201	ESAD	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.6471
p.P261T	DO228974	LICA	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.5919
p.P264T	DO229037	LICA	ICGC	PPLTPLST	DEG_SCF_FBW7_1	0.7031
p.P252S	ACH-000017	Breast Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	0.1111
p.T255P	ACH-000979	Prostate Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	0.1944
p.V258M	ACH-001369	Ovarian Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	0.2778
p.P252L	ACH-002041	Thyroid Cancer	CCLE	PPLTPLST	DEG_SCF_FBW7_1	0.1111
p.H264R	NCI-H838	lung	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	0.8244
p.R268Q	HT-115	large_intestine	COSMIC	PPLTPLST	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPLTPLST

Degron related mutations and impact score

Drug responses associated with EGR2 mutations

All proteins holding degron of PPLTPLST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11161	E3 SUMO-protein ligase EGR2	DEG_SCF_FBW7_1	260:267	PPLTPLST	FBXW7	0.9849	More...