DegronMD - Q13435(SF3B2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P643T	TCGA-21-1082	LUSC	TCGA	PPSY	ITCH	642:645	Mutation altering degron motif	0.7031
p.P643T	DO26463	LUSC	ICGC	PPSY	ITCH	642:645	Mutation altering degron motif	0.7031
p.E729V	TCGA-28-1760	GBM	TCGA	ITPADS	DEG_SCF_FBW7_1	738:743	Mutation rewiring degron network	0.0833
p.E729V	DO13725	GBM	ICGC	ITPADS	DEG_SCF_FBW7_1	738:743	Mutation rewiring degron network	0.0833
p.K697N	TCGA-AP-A0LM	UCEC	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation substituting flanking lysine	0.2778
p.K697N	DO43306	UCEC	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation substituting flanking lysine	0.2778
p.P651S	TCGA-BF-A5ES	SKCM	TCGA	PPSY	ITCH	642:645	Mutation rewiring degron network	0.1667
p.P651S	DO219456	SKCM	ICGC	PPSY	ITCH	642:645	Mutation rewiring degron network	0.1667
p.E693D	TCGA-BS-A0UV	UCEC	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation rewiring degron network	0.0556
p.E693D	DO42793	UCEC	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation rewiring degron network	0.0556
p.P707H	TCGA-D3-A2JD	SKCM	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation altering degron motif	0.7694
p.P707H	DO37543	SKCM	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation altering degron motif	0.7694
p.Q842K	TCGA-ER-A19B	SKCM	TCGA	LAPEELELDPMAM	DEG_ODPH_VHL_1	828:840	Mutation rewiring degron network	0.2778
p.G709W	TCGA-FS-A1ZK	SKCM	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation altering degron motif	0.6714
p.G709W	DO37474	SKCM	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation altering degron motif	0.6714
p.E710K	TCGA-LP-A4AV	CESC	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation altering degron motif	0.7022
p.E710K	DO44275	CESC	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation altering degron motif	0.7022
p.R638Q	DO230347	COCA	ICGC	PPSY	ITCH	642:645	Mutation rewiring degron network	0.2222
p.E717Q	DO48196	ESCA	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation rewiring degron network	0.1389
p.P643L	DO233749	GACA	ICGC	PPSY	ITCH	642:645	Mutation altering degron motif	0.7582
p.M636T	DO233869	GACA	ICGC	PPSY	ITCH	642:645	Mutation rewiring degron network	0.1667
p.P643S	DO220899	MELA	ICGC	PPSY	ITCH	642:645	Mutation altering degron motif	0.6752
p.P713L	DO229446	SKCA	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	703:710	Mutation rewiring degron network	0.25
p.Q825K	DO47491	SKCM	ICGC	LAPEELELDPMAM	DEG_ODPH_VHL_1	828:840	Mutation rewiring degron network	0.25
p.S753L	SIDM00519	Mesothelioma	GDSC	ITPADS	DEG_SCF_FBW7_1	738:743	Mutation rewiring degron network	0.0556
p.S753L	SIDM00519	Mesothelioma	GDSC	DSGLIT	DEG_SCF_TRCP1_1	742:747	Mutation rewiring degron network	0.1667
p.S753L	H2869	pleura	COSMIC	ITPADS	DEG_SCF_FBW7_1	738:743	Mutation rewiring degron network	0.0556
p.S753L	H2869	pleura	COSMIC	DSGLIT	DEG_SCF_TRCP1_1	742:747	Mutation rewiring degron network	0.1667
p.S736L	ACH-002135	Lung Cancer	CCLE	ITPADS	DEG_SCF_FBW7_1	738:743	Mutation rewiring degron network	0.2778
p.S736L	ACH-002135	Lung Cancer	CCLE	DSGLIT	DEG_SCF_TRCP1_1	742:747	Mutation rewiring degron network	0.1667
p.S736L	H2869	pleura	COSMIC	ITPADS	DEG_SCF_FBW7_1	738:743	Mutation rewiring degron network	0.2778
p.S736L	H2869	pleura	COSMIC	DSGLIT	DEG_SCF_TRCP1_1	742:747	Mutation rewiring degron network	0.1667

Kaplan plot for SF3B2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SF3B2

UniProt ID: Q13435

Entrez ID: 10992

Protein name: Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SF3B2 in