DegronMD

Uniprot ID: Q13435

Source protein: Splicing factor 3B subunit 2

Source gene: SF3B2

Class: DEG_SCF_FBW7_1

Location: 738:743

E3 ligase: FBXW7

DEGRON score: 0.8776

ASA_SCORE: 71.95

COIL: 0.8495

CONS_SCORE: 0.3612

DSS_SCORE: 0.7834

HELIX: 0.0478

FCONS_SCORE: 0.9806

RIG_SCORE: 0.6965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E729V	TCGA-28-1760	GBM	TCGA	ITPADS	DEG_SCF_FBW7_1	0.0833
p.E729V	DO13725	GBM	ICGC	ITPADS	DEG_SCF_FBW7_1	0.0833
p.S753L	SIDM00519	Mesothelioma	GDSC	ITPADS	DEG_SCF_FBW7_1	0.0556
p.S753L	H2869	pleura	COSMIC	ITPADS	DEG_SCF_FBW7_1	0.0556
p.S736L	ACH-002135	Lung Cancer	CCLE	ITPADS	DEG_SCF_FBW7_1	0.2778
p.S736L	H2869	pleura	COSMIC	ITPADS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13435	Splicing factor 3B subunit 2	DEG_SCF_FBW7_1	738:743	ITPADS	FBXW7	0.8776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons