DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPEELELDPMAM
Uniprot ID:
Q13435
Source protein:
Splicing factor 3B subunit 2
Source gene:
SF3B2
Class:
DEG_ODPH_VHL_1
Location:
828:840
E3 ligase:
VHL
DEGRON score:
0.9584
ASA_SCORE:
80.7846
COIL:
0.4915
CONS_SCORE:
0.3627
DSS_SCORE:
0.5154
HELIX:
0.4822
FCONS_SCORE:
1.0677
RIG_SCORE:
0.7605
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q842K
TCGA-ER-A19B
SKCM
TCGA
LAPEELELDPMAM
DEG_ODPH_VHL_1
0.2778
p.Q825K
DO47491
SKCM
ICGC
LAPEELELDPMAM
DEG_ODPH_VHL_1
0.25
Drug responses associated with SF3B2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPEELELDPMAM
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13435
Splicing factor 3B subunit 2
DEG_ODPH_VHL_1
828:840
LAPEELELDPMAM
VHL
0.9584
More...