DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGLIT
Uniprot ID:
Q13435
Source protein:
Splicing factor 3B subunit 2
Source gene:
SF3B2
Class:
DEG_SCF_TRCP1_1
Location:
742:747
E3 ligase:
BTRC
DEGRON score:
0.9048
ASA_SCORE:
64.3667
COIL:
0.6967
CONS_SCORE:
0.3706
DSS_SCORE:
0.6934
HELIX:
0.0403
FCONS_SCORE:
0.9974
RIG_SCORE:
0.6563
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S753L
SIDM00519
Mesothelioma
GDSC
DSGLIT
DEG_SCF_TRCP1_1
0.1667
p.S753L
H2869
pleura
COSMIC
DSGLIT
DEG_SCF_TRCP1_1
0.1667
p.S736L
ACH-002135
Lung Cancer
CCLE
DSGLIT
DEG_SCF_TRCP1_1
0.1667
p.S736L
H2869
pleura
COSMIC
DSGLIT
DEG_SCF_TRCP1_1
0.1667
Drug responses associated with SF3B2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGLIT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13435
Splicing factor 3B subunit 2
DEG_SCF_TRCP1_1
742:747
DSGLIT
BTRC
0.9048
More...
Q9UBU7
Protein DBF4 homolog A
DEG_SCF_TRCP1_1
530:535
DSGLIT
BTRC
0.9877
More...