DegronMD

Uniprot ID: Q9UBU7

Source protein: Protein DBF4 homolog A

Source gene: DBF4

Class: DEG_SCF_TRCP1_1

Location: 530:535

E3 ligase: BTRC

DEGRON score: 0.9877

ASA_SCORE: 83.1667

COIL: 0.8608

CONS_SCORE: 0.5537

DSS_SCORE: 0.384

HELIX: 0.0838

FCONS_SCORE: 1.1866

RIG_SCORE: 0.732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L543V	TCGA-06-A6S1	GBM	TCGA	DSGLIT	DEG_SCF_TRCP1_1	0.1111
p.L543V	DO50113	GBM	ICGC	DSGLIT	DEG_SCF_TRCP1_1	0.1111
p.S538G	TCGA-64-5775	LUAD	TCGA	DSGLIT	DEG_SCF_TRCP1_1	0.25
p.S538G	DO26025	LUAD	ICGC	DSGLIT	DEG_SCF_TRCP1_1	0.25
p.G532D	TCGA-85-8479	LUSC	TCGA	DSGLIT	DEG_SCF_TRCP1_1	0.7198
p.G532D	DO45443	LUSC	ICGC	DSGLIT	DEG_SCF_TRCP1_1	0.7198
p.H542D	TCGA-EE-A29S	SKCM	TCGA	DSGLIT	DEG_SCF_TRCP1_1	0.1389
p.H542D	DO37936	SKCM	ICGC	DSGLIT	DEG_SCF_TRCP1_1	0.1389
p.G532S	DO229479	SKCA	ICGC	DSGLIT	DEG_SCF_TRCP1_1	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons