DegronMD

Uniprot ID: Q13435

Source protein: Splicing factor 3B subunit 2

Source gene: SF3B2

Class: DEG_SCF_FBW7_2

Location: 703:710

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 82.225

COIL: 0.7838

CONS_SCORE: 0.5409

DSS_SCORE: 0.8597

HELIX: 0.1024

FCONS_SCORE: 1.427

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K697N	TCGA-AP-A0LM	UCEC	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	0.2778
p.K697N	DO43306	UCEC	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	0.2778
p.E693D	TCGA-BS-A0UV	UCEC	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	0.0556
p.E693D	DO42793	UCEC	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	0.0556
p.P707H	TCGA-D3-A2JD	SKCM	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	0.7694
p.P707H	DO37543	SKCM	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	0.7694
p.G709W	TCGA-FS-A1ZK	SKCM	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	0.6714
p.G709W	DO37474	SKCM	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	0.6714
p.E710K	TCGA-LP-A4AV	CESC	TCGA	IDRTPWGE	DEG_SCF_FBW7_2	0.7022
p.E710K	DO44275	CESC	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	0.7022
p.E717Q	DO48196	ESCA	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	0.1389
p.P713L	DO229446	SKCA	ICGC	IDRTPWGE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13435	Splicing factor 3B subunit 2	DEG_SCF_FBW7_2	703:710	IDRTPWGE	FBXW7	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons