DegronMD - Q96B67(ARRDC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A367V	TCGA-55-8208	LUAD	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.3056
p.A367V	TCGA-FI-A2F4	UCEC	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.3056
p.A367V	DO51192	LUAD	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.3056
p.A367V	DO43434	UCEC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.3056
p.A367S	TCGA-55-8208	LUAD	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.3056
p.A367S	DO51192	LUAD	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.3056
p.E344K	TCGA-A8-A094	BRCA	TCGA	PPSY	ITCH	346:349	Mutation rewiring degron network	0.2778
p.E344K	DO2593	BRCA	ICGC	PPSY	ITCH	346:349	Mutation rewiring degron network	0.2778
p.L337V	TCGA-AA-3977	COAD	TCGA	PPSY	ITCH	346:349	Mutation rewiring degron network	0.0833
p.L337V	DO8730	COAD	ICGC	PPSY	ITCH	346:349	Mutation rewiring degron network	0.0833
p.R359W	TCGA-AP-A051	UCEC	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8634
p.R359W	TCGA-BS-A0UV	UCEC	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8634
p.R359W	DO42793	UCEC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8634
p.R359W	DO42673	UCEC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8634
p.R359W	SIDM00217	Colorectal Carcinoma	GDSC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8634
p.R359W	ACH-000999	Colon/Colorectal Cancer	CCLE	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8634
p.R359W	SNU-1040	large intestine	COSMIC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8634
p.G132D	TCGA-AX-A0J1	UCEC	TCGA	LPQTPLAT	DEG_SCF_FBW7_1	118:125	Mutation rewiring degron network	0.1389
p.G132D	DO41199	UCEC	ICGC	LPQTPLAT	DEG_SCF_FBW7_1	118:125	Mutation rewiring degron network	0.1389
p.R135C	TCGA-AX-A2HC	UCEC	TCGA	LPQTPLAT	DEG_SCF_FBW7_1	118:125	Mutation rewiring degron network	0.0556
p.R135C	DO41572	UCEC	ICGC	LPQTPLAT	DEG_SCF_FBW7_1	118:125	Mutation rewiring degron network	0.0556
p.Y349C	TCGA-BT-A20N	BLCA	TCGA	PPSY	ITCH	346:349	Mutation altering degron motif	0.7087
p.Y349C	DO550	BLCA	ICGC	PPSY	ITCH	346:349	Mutation altering degron motif	0.7087
p.E396K	TCGA-C5-A8YR	CESC	TCGA	PPLY	ITCH	391:394	Mutation rewiring degron network	0.2778
p.E396K	DO49908	CESC	ICGC	PPLY	ITCH	391:394	Mutation rewiring degron network	0.2778
p.N360D	TCGA-CM-4743	COAD	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.5821
p.N360D	DO8103	COAD	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.5821
p.P401S	TCGA-EE-A2GI	SKCM	TCGA	PPLY	ITCH	391:394	Mutation rewiring degron network	0.1389
p.P401S	DO37410	SKCM	ICGC	PPLY	ITCH	391:394	Mutation rewiring degron network	0.1389
p.L339R	TCGA-P4-A5E6	KIRP	TCGA	PPSY	ITCH	346:349	Mutation rewiring degron network	0.1389
p.L339R	DO48513	KIRP	ICGC	PPSY	ITCH	346:349	Mutation rewiring degron network	0.1389
p.P391S	TCGA-W3-AA21	SKCM	TCGA	PPLY	ITCH	391:394	Mutation altering degron motif	0.6752
p.P391S	DO51278	SKCM	ICGC	PPLY	ITCH	391:394	Mutation altering degron motif	0.6752
p.Q384L	DO49260	ALL	ICGC	PPLY	ITCH	391:394	Mutation rewiring degron network	0.1389
p.N360H	DO223875	AML	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.6312
p.A374D	DO228976	LICA	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.1111
p.A374D	DO229031	LICA	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation rewiring degron network	0.1111
p.Q384K	DO229026	LICA	ICGC	PPLY	ITCH	391:394	Mutation rewiring degron network	0.1389
p.A113E	DO229041	LICA	ICGC	LPQTPLAT	DEG_SCF_FBW7_1	118:125	Mutation rewiring degron network	0.1944
p.P343T	DO229045	LICA	ICGC	PPSY	ITCH	346:349	Mutation rewiring degron network	0.25
p.Q403H	DO231739	LINC	ICGC	PPLY	ITCH	391:394	Mutation rewiring degron network	0.0833
p.R358K	DO231730	LINC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.6126
p.P392L	DO232761	PBCA	ICGC	PPLY	ITCH	391:394	Mutation altering degron motif	0.7582
p.S338L	DO218860	SKCA	ICGC	PPSY	ITCH	346:349	Mutation rewiring degron network	0.1111
p.L362R	SIDM00684	Glioblastoma	GDSC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8428
p.L362R	LN-229	central nervous system	COSMIC	RRNNLAPVS	DEG_APCC_DBOX_1	358:366	Mutation altering degron motif	0.8428
p.P391T	SIDM00120	Prostate Carcinoma	GDSC	PPLY	ITCH	391:394	Mutation altering degron motif	0.7031
p.P391T	ACH-000979	Prostate Cancer	CCLE	PPLY	ITCH	391:394	Mutation altering degron motif	0.7031
p.P391T	DU-145	prostate	COSMIC	PPLY	ITCH	391:394	Mutation altering degron motif	0.7031
p.I397V	SIDM00333	Endometrial Carcinoma	GDSC	PPLY	ITCH	391:394	Mutation rewiring degron network	0.25
p.I397V	MFE-319	endometrium	COSMIC	PPLY	ITCH	391:394	Mutation rewiring degron network	0.25
p.S336R	SIDM00596	Endometrial Carcinoma	GDSC	PPSY	ITCH	346:349	Mutation rewiring degron network	0.0556
p.S336R	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	346:349	Mutation rewiring degron network	0.0556
p.S336R	HEC-1	endometrium	COSMIC	PPSY	ITCH	346:349	Mutation rewiring degron network	0.0556

Kaplan plot for ARRDC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARRDC3

UniProt ID: Q96B67

Entrez ID: 57561

Protein name: Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARRDC3 in