DegronMD

Uniprot ID: Q96B67

Source protein: Arrestin domain-containing protein 3

Source gene: ARRDC3

Class: DEG_SCF_FBW7_1

Location: 118:125

E3 ligase: FBXW7

DEGRON score: 0.9905

ASA_SCORE: 50.1

COIL: 0.9001

CONS_SCORE: 0.6256

DSS_SCORE: 0.3317

HELIX: 0.01

FCONS_SCORE: 0.875

RIG_SCORE: 0.7593

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G132D	TCGA-AX-A0J1	UCEC	TCGA	LPQTPLAT	DEG_SCF_FBW7_1	0.1389
p.G132D	DO41199	UCEC	ICGC	LPQTPLAT	DEG_SCF_FBW7_1	0.1389
p.R135C	TCGA-AX-A2HC	UCEC	TCGA	LPQTPLAT	DEG_SCF_FBW7_1	0.0556
p.R135C	DO41572	UCEC	ICGC	LPQTPLAT	DEG_SCF_FBW7_1	0.0556
p.A113E	DO229041	LICA	ICGC	LPQTPLAT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96B67	Arrestin domain-containing protein 3	DEG_SCF_FBW7_1	118:125	LPQTPLAT	FBXW7	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons