DegronMD

Uniprot ID: Q96B67

Source protein: Arrestin domain-containing protein 3

Source gene: ARRDC3

Class: DEG_APCC_DBOX_1

Location: 358:366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8376

ASA_SCORE: 79.3556

COIL: 0.7738

CONS_SCORE: 0.4638

DSS_SCORE: 0.4007

HELIX: 0.1858

FCONS_SCORE: 0.7782

RIG_SCORE: 0.7361

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A367V	TCGA-55-8208	LUAD	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	0.3056
p.A367V	TCGA-FI-A2F4	UCEC	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	0.3056
p.A367V	DO51192	LUAD	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.3056
p.A367V	DO43434	UCEC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.3056
p.A367S	TCGA-55-8208	LUAD	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	0.3056
p.A367S	DO51192	LUAD	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.3056
p.R359W	TCGA-AP-A051	UCEC	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	0.8634
p.R359W	TCGA-BS-A0UV	UCEC	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	0.8634
p.R359W	DO42793	UCEC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.8634
p.R359W	DO42673	UCEC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.8634
p.R359W	SIDM00217	Colorectal Carcinoma	GDSC	RRNNLAPVS	DEG_APCC_DBOX_1	0.8634
p.R359W	ACH-000999	Colon/Colorectal Cancer	CCLE	RRNNLAPVS	DEG_APCC_DBOX_1	0.8634
p.R359W	SNU-1040	large_intestine	COSMIC	RRNNLAPVS	DEG_APCC_DBOX_1	0.8634
p.N360D	TCGA-CM-4743	COAD	TCGA	RRNNLAPVS	DEG_APCC_DBOX_1	0.5821
p.N360D	DO8103	COAD	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.5821
p.N360H	DO223875	AML	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.6312
p.A374D	DO228976	LICA	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.1111
p.A374D	DO229031	LICA	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.1111
p.R358K	DO231730	LINC	ICGC	RRNNLAPVS	DEG_APCC_DBOX_1	0.6126
p.L362R	SIDM00684	Glioblastoma	GDSC	RRNNLAPVS	DEG_APCC_DBOX_1	0.8428
p.L362R	LN-229	central_nervous_system	COSMIC	RRNNLAPVS	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96B67	Arrestin domain-containing protein 3	DEG_APCC_DBOX_1	358:366	RRNNLAPVS	APC,CDC20,FZR1	0.8376	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons