DegronMD - Q9ULQ0(STRIP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V311L	TCGA-20-1686	OV	TCGA	PPSY	ITCH	319:322	Mutation rewiring degron network	0.1111
p.V311L	DO31380	OV	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.1111
p.R346S	TCGA-29-1698	OV	TCGA	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0833
p.R346S	TCGA-CV-A6JD	HNSC	TCGA	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0833
p.R346S	DO49035	HNSC	ICGC	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0833
p.R346S	DO28531	OV	ICGC	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0833
p.M314I	TCGA-2J-AABA	PAAD	TCGA	PPSY	ITCH	319:322	Mutation rewiring degron network	0.1944
p.M314I	DO51659	PAAD	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.1944
p.S354N	TCGA-AZ-4315	COAD	TCGA	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.75
p.S354N	DO8842	COAD	ICGC	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.75
p.P319L	TCGA-BR-4201	STAD	TCGA	PPSY	ITCH	319:322	Mutation altering degron motif	0.7582
p.P319L	DO38707	STAD	ICGC	PPSY	ITCH	319:322	Mutation altering degron motif	0.7582
p.R315C	TCGA-BR-8487	STAD	TCGA	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.R315C	TCGA-CM-6674	COAD	TCGA	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.R315C	TCGA-EY-A215	UCEC	TCGA	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.R315C	DO225367	BRCA	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.R315C	DO10092	COAD	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.R315C	DO228138	PBCA	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.R315C	DO47867	STAD	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.R315C	DO42665	UCEC	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2222
p.F364L	TCGA-E2-A1LG	BRCA	TCGA	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.F364L	DO4018	BRCA	ICGC	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2222
p.S318F	TCGA-EJ-5507	PRAD	TCGA	PPSY	ITCH	319:322	Mutation blocking phosphorylation signal	0.75
p.S318F	DO36257	PRAD	ICGC	PPSY	ITCH	319:322	Mutation blocking phosphorylation signal	0.75
p.P320S	TCGA-F7-A624	HNSC	TCGA	PPSY	ITCH	319:322	Mutation altering degron motif	0.6752
p.P320S	DO44440	HNSC	ICGC	PPSY	ITCH	319:322	Mutation altering degron motif	0.6752
p.Q309K	TCGA-IB-7651	PAAD	TCGA	PPSY	ITCH	319:322	Mutation rewiring degron network	0.0556
p.Q309K	DO46657	PAAD	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.0556
p.L324F	DO220893	MELA	ICGC	PPSY	ITCH	319:322	Mutation rewiring degron network	0.2778
p.A370T	DO50712	ORCA	ICGC	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.A370T	SIDM00493	Other Solid Cancers	GDSC	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.R345Q	SIDM01588	Endometrial Carcinoma	GDSC	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.R345Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	LDIYNE	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556

Kaplan plot for STRIP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STRIP2

UniProt ID: Q9ULQ0

Entrez ID: 57464

Protein name: Striatin-interacting protein 2 (Protein FAM40B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STRIP2 in