DegronMD

Uniprot ID: Q9ULQ0

Source protein: Striatin-interacting protein 2

Source gene: STRIP2

Class: LIG_APCC_ABBA_1

Location: 355:360

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9626

ASA_SCORE: 84.5667

COIL: 0.5765

CONS_SCORE: 0.2932

DSS_SCORE: 0.5224

HELIX: 0.3782

FCONS_SCORE: 1.0255

RIG_SCORE: 0.7676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R346S	TCGA-29-1698	OV	TCGA	LDIYNE	LIG_APCC_ABBA_1	0.0833
p.R346S	TCGA-CV-A6JD	HNSC	TCGA	LDIYNE	LIG_APCC_ABBA_1	0.0833
p.R346S	DO49035	HNSC	ICGC	LDIYNE	LIG_APCC_ABBA_1	0.0833
p.R346S	DO28531	OV	ICGC	LDIYNE	LIG_APCC_ABBA_1	0.0833
p.S354N	TCGA-AZ-4315	COAD	TCGA	LDIYNE	LIG_APCC_ABBA_1	0.75
p.S354N	DO8842	COAD	ICGC	LDIYNE	LIG_APCC_ABBA_1	0.75
p.F364L	TCGA-E2-A1LG	BRCA	TCGA	LDIYNE	LIG_APCC_ABBA_1	0.2222
p.F364L	DO4018	BRCA	ICGC	LDIYNE	LIG_APCC_ABBA_1	0.2222
p.A370T	DO50712	ORCA	ICGC	LDIYNE	LIG_APCC_ABBA_1	0.0556
p.A370T	SIDM00493	Other Solid Cancers	GDSC	LDIYNE	LIG_APCC_ABBA_1	0.0556
p.R345Q	SIDM01588	Endometrial Carcinoma	GDSC	LDIYNE	LIG_APCC_ABBA_1	0.0556
p.R345Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	LDIYNE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULQ0	Striatin-interacting protein 2	LIG_APCC_ABBA_1	355:360	LDIYNE	APC,CDC20,FZR1	0.9626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons