DegronMD - O15350(TP73)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P483L	TCGA-B7-A5TI	STAD	TCGA	PPPY	ITCH	484:487	Mutation rewiring degron network	0.3056
p.P483L	DO222328	STAD	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.3056
p.G12D	TCGA-D1-A16Y	UCEC	TCGA	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.25
p.G12D	DO41524	UCEC	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.25
p.R493C	DO48583	BLCA	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1667
p.R493C	DO43755	UCEC	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1667
p.P7A	DO229355	BTCA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation blocking phosphorylation signal	0.5556
p.R495H	DO8159	COAD	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1111
p.R495H	DO232224	PBCA	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1111
p.R414W	DO10582	COAD	ICGC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.1389
p.R414W	DO41871	UCEC	ICGC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.1389
p.A12T	DO233652	GACA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.25
p.A6T	DO233935	GACA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.0833
p.R9L	DO228985	LICA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.1667
p.G477V	DO228986	LICA	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1389
p.S20I	DO229029	LICA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation altering degron motif	0.623
p.D30Y	DO229022	LICA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.1111
p.R495C	DO228338	MALY	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1111
p.S474F	DO220857	MELA	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.0556
p.Y412C	DO51407	PRAD	ICGC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.1944
p.P400R	DO47253	SKCM	ICGC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.2222
p.R401W	DO47253	SKCM	ICGC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.25
p.A489T	DO47584	SKCM	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.2778
p.P413S	DO51276	SKCM	ICGC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.1667
p.R483H	DO48184	UCEC	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.3056
p.R485W	DO43298	UCEC	ICGC	PPPY	ITCH	484:487	Mutation altering degron motif	0.8634
p.H491R	DO41999	UCEC	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.2222
p.P407S	DO41999	UCEC	ICGC	PPSY	ITCH	404:407	Mutation altering degron motif	0.6752
p.C406S	DO43907	UCEC	ICGC	PPSY	ITCH	404:407	Mutation altering degron motif	0.7541
p.R483C	DO43755	UCEC	ICGC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.3056
p.T13M	SIDM01943	Colorectal Carcinoma	GDSC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.2778
p.T13M	SIDM00051	Chondrosarcoma	GDSC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.2778
p.T13M	CHSA0011	bone	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.2778
p.L402R	SIDM00999	Bladder Carcinoma	GDSC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.2778
p.L402R	ACH-000973	Bladder Cancer	CCLE	PPSY	ITCH	404:407	Mutation rewiring degron network	0.2778
p.L402R	639-V	urinary tract	COSMIC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.2778
p.G478R	SIDM00500	Colorectal Carcinoma	GDSC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1667
p.G478R	ACH-000959	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1667
p.S477L	SIDM01588	Endometrial Carcinoma	GDSC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1389
p.S477L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1389
p.P24L	ACH-000192	Endometrial/Uterine Cancer	CCLE	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.2778
p.Y487H	ACH-000977	lymph node	CCLE	PPPY	ITCH	484:487	Mutation altering degron motif	0.7229
p.Y487H	LNCaP-Clone-FGC	prostate	COSMIC	PPPY	ITCH	484:487	Mutation altering degron motif	0.7229
p.P27S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation blocking phosphorylation signal	0.6389
p.A401T	SNU-175	large intestine	COSMIC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.25
p.A401T	MC-IXC	autonomic ganglia	COSMIC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.25
p.M23L	LNCaP-Clone-FGC	prostate	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.3056
p.R395C	HEC-1	endometrium	COSMIC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.0833
p.A8V	SW156	kidney	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation blocking phosphorylation signal	0.5833
p.Y483C	T-T	oesophagus	COSMIC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.3056
p.A30V	SW156	kidney	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	15:22	Mutation rewiring degron network	0.1111
p.W497G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.0556
p.Y488C	CW-2	large intestine	COSMIC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.3056
p.Y416H	LNCaP-Clone-FGC	prostate	COSMIC	PPSY	ITCH	404:407	Mutation substituting flanking lysine	0.1944
p.W401G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	404:407	Mutation rewiring degron network	0.25
p.L479R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	484:487	Mutation rewiring degron network	0.1944

Kaplan plot for TP73 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TP73

UniProt ID: O15350

Entrez ID: 7161

Protein name: Tumor protein p73 (p53-like transcription factor) (p53-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TP73 in