DegronMD

Uniprot ID: O15350

Source protein: Tumor protein p73

Source gene: TP73

Class: DEG_MDM2_SWIB_1

Location: 15:22

E3 ligase: MDM2

DEGRON score: 0.9926

ASA_SCORE: 46.65

COIL: 0.2545

CONS_SCORE: 0.3725

DSS_SCORE: 0.5302

HELIX: 0.7259

FCONS_SCORE: 1.0863

RIG_SCORE: 0.7708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G12D	TCGA-D1-A16Y	UCEC	TCGA	FEHLWSSL	DEG_MDM2_SWIB_1	0.25
p.G12D	DO41524	UCEC	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	0.25
p.P7A	DO229355	BTCA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	0.5556
p.A12T	DO233652	GACA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	0.25
p.A6T	DO233935	GACA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	0.0833
p.R9L	DO228985	LICA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	0.1667
p.S20I	DO229029	LICA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	0.623
p.D30Y	DO229022	LICA	ICGC	FEHLWSSL	DEG_MDM2_SWIB_1	0.1111
p.T13M	SIDM01943	Colorectal Carcinoma	GDSC	FEHLWSSL	DEG_MDM2_SWIB_1	0.2778
p.T13M	SIDM00051	Chondrosarcoma	GDSC	FEHLWSSL	DEG_MDM2_SWIB_1	0.2778
p.T13M	CHSA0011	bone	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	0.2778
p.P24L	ACH-000192	Endometrial/Uterine Cancer	CCLE	FEHLWSSL	DEG_MDM2_SWIB_1	0.2778
p.P27S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	0.6389
p.M23L	LNCaP-Clone-FGC	prostate	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	0.3056
p.A8V	SW156	kidney	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	0.5833
p.A30V	SW156	kidney	COSMIC	FEHLWSSL	DEG_MDM2_SWIB_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15350	Tumor protein p73	DEG_MDM2_SWIB_1	15:22	FEHLWSSL	MDM2	0.9926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons