DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPSY
Uniprot ID:
Q9Y5R6
Source protein:
Doublesex- and mab-3-related transcription factor 1
Source gene:
DMRT1
Class:
ITCH
Location:
296:299
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.7856
ASA_SCORE:
66.6
COIL:
0.8088
CONS_SCORE:
0.6312
DSS_SCORE:
0.3369
HELIX:
0.126
FCONS_SCORE:
1.0468
RIG_SCORE:
0.6513
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S298F
DO222731
MELA
ICGC
PPSY
ITCH
0.6871
p.L300P
TCGA-AJ-A8CW
UCEC
TCGA
PPSY
ITCH
0.3056
p.L300P
DO52400
UCEC
ICGC
PPSY
ITCH
0.3056
p.P295L
TCGA-DF-A2KZ
UCEC
TCGA
PPSY
ITCH
0.3056
p.P295L
DO52409
UCEC
ICGC
PPSY
ITCH
0.3056
p.P295L
SIDM00812
Colorectal Carcinoma
GDSC
PPSY
ITCH
0.3056
p.P295L
SW1417
large_intestine
COSMIC
PPSY
ITCH
0.3056
p.G301D
TCGA-FI-A2D5
UCEC
TCGA
PPSY
ITCH
0.2778
p.G301D
DO222908
MELA
ICGC
PPSY
ITCH
0.2778
p.G301D
DO41331
UCEC
ICGC
PPSY
ITCH
0.2778
p.Y293F
DO51962
PRAD
ICGC
PPSY
ITCH
0.25
p.S292Y
TCGA-B5-A0JY
UCEC
TCGA
PPSY
ITCH
0.2222
p.S292Y
DO43041
UCEC
ICGC
PPSY
ITCH
0.2222
p.S292F
TCGA-D3-A1QA
SKCM
TCGA
PPSY
ITCH
0.2222
p.S292F
DO47469
SKCM
ICGC
PPSY
ITCH
0.2222
p.H291Y
TCGA-13-0888
OV
TCGA
PPSY
ITCH
0.1944
p.H291Y
DO30420
OV
ICGC
PPSY
ITCH
0.1944
p.V304M
TCGA-4L-AA1F
PRAD
TCGA
PPSY
ITCH
0.1944
p.V304M
DO219247
PRAD
ICGC
PPSY
ITCH
0.1944
p.V304M
SIDM00744
Non-Small Cell Lung Carcinoma
GDSC
PPSY
ITCH
0.1944
p.R289K
TCGA-EB-A551
SKCM
TCGA
PPSY
ITCH
0.1389
p.R289K
DO47453
SKCM
ICGC
PPSY
ITCH
0.1389
p.F307L
TCGA-63-A5MT
LUSC
TCGA
PPSY
ITCH
0.1111
p.F307L
DO219163
LUSC
ICGC
PPSY
ITCH
0.1111
p.F307L
SIDM00285
Neuroblastoma
GDSC
PPSY
ITCH
0.1111
Showing 1 to 25 of 29 entries
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Drug responses associated with DMRT1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PPSY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z5R6
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
ITCH
587:590
PPSY
ITCH,NEDD4
0.737
More...
Q96KQ4
Apoptosis-stimulating of p53 protein 1
ITCH
459:462
PPSY
ITCH,NEDD4
0.9751
More...
Q8N5I2
Arrestin domain-containing protein 1
ITCH
415:418
PPSY
ITCH,NEDD4
0.9903
More...
Q96B67
Arrestin domain-containing protein 3
ITCH
346:349
PPSY
ITCH,NEDD4
0.77
More...
Q96J65
ATP-binding cassette sub-family C member 12
ITCH
420:423
PPSY
ITCH,NEDD4
0.6228
More...
Q8N2M8
CLK4-associating serine/arginine rich protein
ITCH
286:289
PPSY
ITCH,NEDD4
0.9968
More...
A6NKD9
Coiled-coil domain-containing protein 85C
ITCH
316:319
PPSY
ITCH,NEDD4
0.9875
More...
Q99715
Collagen alpha-1
ITCH
2574:2577
PPSY
ITCH,NEDD4
0.6822
More...
Q96EP5
DAZ-associated protein 1
ITCH
370:373
PPSY
ITCH,NEDD4
0.9278
More...
Q9H7D0
Dedicator of cytokinesis protein 5
ITCH
1438:1441
PPSY
ITCH,NEDD4
0.5355
More...
O94850
Dendrin
ITCH
200:203
PPSY
ITCH,NEDD4
0.8751
More...
O94850
Dendrin
ITCH
230:233
PPSY
ITCH,NEDD4
0.9726
More...
Q9UBP4
Dickkopf-related protein 3
ITCH
91:94
PPSY
ITCH,NEDD4
0.9656
More...
Q9Y5R6
Doublesex- and mab-3-related transcription factor 1
ITCH
296:299
PPSY
ITCH,NEDD4
0.7856
More...
P11161
E3 SUMO-protein ligase EGR2
ITCH
205:208
PPSY
ITCH,NEDD4
0.9358
More...
Q7Z6E9
E3 ubiquitin-protein ligase RBBP6
ITCH
156:159
PPSY
ITCH,NEDD4
0.9269
More...
Q9NT22
EMILIN-3
ITCH
160:163
PPSY
ITCH,NEDD4
0.9466
More...
Q9NRM1
Enamelin
ITCH
853:856
PPSY
ITCH,NEDD4
0.9682
More...
Q14511
Enhancer of filamentation 1
ITCH
109:112
PPSY
ITCH,NEDD4
0.9998
More...
Q6NXG1
Epithelial splicing regulatory protein 1
ITCH
554:557
PPSY
ITCH,NEDD4
0.6605
More...
P19235
Erythropoietin receptor
ITCH
501:504
PPSY
ITCH,NEDD4
0.9994
More...
Q53EP0
Fibronectin type III domain-containing protein 3B
ITCH
110:113
PPSY
ITCH,NEDD4
0.9629
More...
Q5HY92
Fidgetin
ITCH
401:404
PPSY
ITCH,NEDD4
0.9941
More...
Q9BQQ3
Golgi reassembly-stacking protein 1
ITCH
206:209
PPSY
ITCH,NEDD4
0.9258
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
714:717
PPSY
ITCH,NEDD4
0.9896
More...
Showing 1 to 25 of 127 entries
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