DegronMD - Q53EP0(FNDC3B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T566R	TCGA-43-7658	LUSC	TCGA	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7876
p.T566R	DO27628	LUSC	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7876
p.T566R	SIDM00730	Small Cell Lung Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7876
p.T566R	ACH-000610	Lung Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7876
p.T566R	NCI-H2227	lung	COSMIC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7876
p.I86L	TCGA-5C-A9VG	LIHC	TCGA	PPGY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.I86L	DO52163	LIHC	ICGC	PPGY	ITCH	82:85	Mutation rewiring degron network	0.3056
p.T566M	TCGA-5M-AAT6	COAD	TCGA	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7423
p.T566M	DO223703	COAD	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7423
p.T566M	SIDM00332	Breast Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7423
p.T566M	ACH-001819	Breast Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7423
p.T566M	MFM-223	breast	COSMIC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7423
p.P578L	TCGA-68-7755	LUSC	TCGA	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.P578L	DO26512	LUSC	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.I200N	TCGA-A4-A4ZT	KIRP	TCGA	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.0833
p.I200N	DO44465	KIRP	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.0833
p.R198H	TCGA-A6-2686	COAD	TCGA	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1389
p.R198H	DO7828	COAD	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1389
p.S560R	TCGA-BG-A0MG	UCEC	TCGA	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2222
p.S560R	DO42057	UCEC	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2222
p.C108Y	TCGA-BR-A4CQ	STAD	TCGA	PPSY	ITCH	110:113	Mutation rewiring degron network	0.2778
p.C108Y	DO47861	STAD	ICGC	PPSY	ITCH	110:113	Mutation rewiring degron network	0.2778
p.H122R	TCGA-D7-6818	STAD	TCGA	PPSY	ITCH	110:113	Mutation rewiring degron network	0.0833
p.H122R	DO38262	STAD	ICGC	PPSY	ITCH	110:113	Mutation rewiring degron network	0.0833
p.P106L	TCGA-EE-A17X	SKCM	TCGA	PPSY	ITCH	110:113	Mutation rewiring degron network	0.2222
p.P106L	DO37931	SKCM	ICGC	PPSY	ITCH	110:113	Mutation rewiring degron network	0.2222
p.G95E	TCGA-EO-A22U	UCEC	TCGA	PPGY	ITCH	82:85	Mutation rewiring degron network	0.0556
p.G95E	DO43755	UCEC	ICGC	PPGY	ITCH	82:85	Mutation rewiring degron network	0.0556
p.K556N	TCGA-EO-A22X	UCEC	TCGA	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.2222
p.K556N	DO43907	UCEC	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.2222
p.R183Q	TCGA-EO-A3AY	UCEC	TCGA	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.2778
p.R183Q	DO43202	UCEC	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.2778
p.T567M	TCGA-XF-A9T8	BLCA	TCGA	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7423
p.T567M	DO51927	BLCA	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7423
p.T179S	DO229010	COCA	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1667
p.T179S	DO229013	COCA	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1667
p.T179S	DO229003	COCA	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1667
p.T179S	DO229346	LAML	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1667
p.T179S	DO229480	LAML	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1667
p.T179S	DO228947	LICA	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.1667
p.L123F	DO233126	GACA	ICGC	PPSY	ITCH	110:113	Mutation rewiring degron network	0.0556
p.V564F	DO228976	LICA	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7068
p.V564F	DO229009	LICA	ICGC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7068
p.G84C	DO229034	LICA	ICGC	PPGY	ITCH	82:85	Mutation altering degron motif	0.6489
p.H192Q	DO48973	PBCA	ICGC	DQYSKPP	CBL_PTK	185:191	Mutation rewiring degron network	0.3056
p.G74E	DO232761	PBCA	ICGC	PPGY	ITCH	82:85	Mutation rewiring degron network	0.1111
p.P111Q	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	110:113	Mutation altering degron motif	0.7035
p.P111Q	ACH-000636	Leukemia	CCLE	PPSY	ITCH	110:113	Mutation altering degron motif	0.7035
p.P111Q	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	110:113	Mutation altering degron motif	0.7035
p.S188N	SIDM00120	Prostate Carcinoma	GDSC	DQYSKPP	CBL_PTK	185:191	Mutation altering degron motif	0.7069
p.S188N	ACH-000979	Prostate Cancer	CCLE	DQYSKPP	CBL_PTK	185:191	Mutation altering degron motif	0.7069
p.S188N	DU-145	prostate	COSMIC	DQYSKPP	CBL_PTK	185:191	Mutation altering degron motif	0.7069
p.R577G	SIDM00537	Colorectal Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.R577G	ACH-000982	Colon/Colorectal Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.R577G	ACH-001345	Colon/Colorectal Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.R577G	GP5d	large intestine	COSMIC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0833
p.P191L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DQYSKPP	CBL_PTK	185:191	Mutation altering degron motif	0.7582
p.P191L	ACH-000918	Leukemia	CCLE	DQYSKPP	CBL_PTK	185:191	Mutation altering degron motif	0.7582
p.P191L	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	DQYSKPP	CBL_PTK	185:191	Mutation altering degron motif	0.7582
p.S557G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.S557G	ACH-000937	Leukemia	CCLE	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.S557G	PF-382	haematopoietic and lymphoid tissue	COSMIC	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.L563V	ACH-002647	Gastric Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FNDC3B

UniProt ID: Q53EP0

Entrez ID: 64778

Protein name: Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FNDC3B in