DegronMD

Uniprot ID: Q53EP0

Source protein: Fibronectin type III domain-containing protein 3B

Source gene: FNDC3B

Class: DEG_SPOP_SBC_1

Location: 564:568

E3 ligase: SPOP

DEGRON score: 0.9058

ASA_SCORE: 48.88

COIL: 0.353

CONS_SCORE: 0.5886

DSS_SCORE: 0.4998

HELIX: 0.0068

FCONS_SCORE: 0.906

RIG_SCORE: 0.7533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T566R	TCGA-43-7658	LUSC	TCGA	VCTTS	DEG_SPOP_SBC_1	0.7876
p.T566R	DO27628	LUSC	ICGC	VCTTS	DEG_SPOP_SBC_1	0.7876
p.T566R	SIDM00730	Small Cell Lung Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	0.7876
p.T566R	ACH-000610	Lung Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	0.7876
p.T566R	NCI-H2227	lung	COSMIC	VCTTS	DEG_SPOP_SBC_1	0.7876
p.T566M	TCGA-5M-AAT6	COAD	TCGA	VCTTS	DEG_SPOP_SBC_1	0.7423
p.T566M	DO223703	COAD	ICGC	VCTTS	DEG_SPOP_SBC_1	0.7423
p.T566M	SIDM00332	Breast Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	0.7423
p.T566M	ACH-001819	Breast Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	0.7423
p.T566M	MFM-223	breast	COSMIC	VCTTS	DEG_SPOP_SBC_1	0.7423
p.P578L	TCGA-68-7755	LUSC	TCGA	VCTTS	DEG_SPOP_SBC_1	0.0556
p.P578L	DO26512	LUSC	ICGC	VCTTS	DEG_SPOP_SBC_1	0.0556
p.S560R	TCGA-BG-A0MG	UCEC	TCGA	VCTTS	DEG_SPOP_SBC_1	0.2222
p.S560R	DO42057	UCEC	ICGC	VCTTS	DEG_SPOP_SBC_1	0.2222
p.K556N	TCGA-EO-A22X	UCEC	TCGA	VCTTS	DEG_SPOP_SBC_1	0.2222
p.K556N	DO43907	UCEC	ICGC	VCTTS	DEG_SPOP_SBC_1	0.2222
p.T567M	TCGA-XF-A9T8	BLCA	TCGA	VCTTS	DEG_SPOP_SBC_1	0.7423
p.T567M	DO51927	BLCA	ICGC	VCTTS	DEG_SPOP_SBC_1	0.7423
p.V564F	DO228976	LICA	ICGC	VCTTS	DEG_SPOP_SBC_1	0.7068
p.V564F	DO229009	LICA	ICGC	VCTTS	DEG_SPOP_SBC_1	0.7068
p.R577G	SIDM00537	Colorectal Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	0.0833
p.R577G	ACH-000982	Colon/Colorectal Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	0.0833
p.R577G	ACH-001345	Colon/Colorectal Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	0.0833
p.R577G	GP5d	large_intestine	COSMIC	VCTTS	DEG_SPOP_SBC_1	0.0833
p.S557G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VCTTS	DEG_SPOP_SBC_1	0.1389
p.S557G	ACH-000937	Leukemia	CCLE	VCTTS	DEG_SPOP_SBC_1	0.1389
p.S557G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VCTTS	DEG_SPOP_SBC_1	0.1389
p.L563V	ACH-002647	Gastric Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75143	Autophagy-related protein 13	DEG_SPOP_SBC_1	251:255	VCTTS	SPOP	0.9964	More...
Q53EP0	Fibronectin type III domain-containing protein 3B	DEG_SPOP_SBC_1	564:568	VCTTS	SPOP	0.9058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VCTTS

Degron related mutations and impact score

Drug responses associated with FNDC3B mutations

All proteins holding degron of VCTTS