DegronMD - O75143(ATG13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T253A	TCGA-CV-5436	HNSC	TCGA	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7139
p.T253A	DO15006	HNSC	ICGC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7139
p.S259F	TCGA-DX-A8BP	SARC	TCGA	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.S259F	DO220056	SARC	ICGC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.S265L	DO219728	CESC	ICGC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0556
p.P243S	DO220881	MELA	ICGC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1111
p.F256L	SIDM00600	Thyroid Gland Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.3056
p.F256L	IHH-4	thyroid	COSMIC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.3056
p.G259V	ACH-000747	Lung Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.G259V	NCI-H1703	lung	COSMIC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.V262I	ACH-002291	Embryonal Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389
p.V262I	NTERA-2_cl_D1	testis	COSMIC	VCTTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons