DegronMD

Uniprot ID: O75143

Source protein: Autophagy-related protein 13

Source gene: ATG13

Class: DEG_SPOP_SBC_1

Location: 251:255

E3 ligase: SPOP

DEGRON score: 0.9964

ASA_SCORE: 67.98

COIL: 0.7332

CONS_SCORE: 0.3925

DSS_SCORE: 0.5167

HELIX: 0.0854

FCONS_SCORE: 1.0716

RIG_SCORE: 0.7812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T253A	TCGA-CV-5436	HNSC	TCGA	VCTTS	DEG_SPOP_SBC_1	0.7139
p.T253A	DO15006	HNSC	ICGC	VCTTS	DEG_SPOP_SBC_1	0.7139
p.S259F	TCGA-DX-A8BP	SARC	TCGA	VCTTS	DEG_SPOP_SBC_1	0.2222
p.S259F	DO220056	SARC	ICGC	VCTTS	DEG_SPOP_SBC_1	0.2222
p.S265L	DO219728	CESC	ICGC	VCTTS	DEG_SPOP_SBC_1	0.0556
p.P243S	DO220881	MELA	ICGC	VCTTS	DEG_SPOP_SBC_1	0.1111
p.F256L	SIDM00600	Thyroid Gland Carcinoma	GDSC	VCTTS	DEG_SPOP_SBC_1	0.3056
p.F256L	IHH-4	thyroid	COSMIC	VCTTS	DEG_SPOP_SBC_1	0.3056
p.G259V	ACH-000747	Lung Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	0.2222
p.G259V	NCI-H1703	lung	COSMIC	VCTTS	DEG_SPOP_SBC_1	0.2222
p.V262I	ACH-002291	Embryonal Cancer	CCLE	VCTTS	DEG_SPOP_SBC_1	0.1389
p.V262I	NTERA-2_cl_D1	testis	COSMIC	VCTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75143	Autophagy-related protein 13	DEG_SPOP_SBC_1	251:255	VCTTS	SPOP	0.9964	More...
Q53EP0	Fibronectin type III domain-containing protein 3B	DEG_SPOP_SBC_1	564:568	VCTTS	SPOP	0.9058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons