DegronMD

Uniprot ID: Q53EP0

Source protein: Fibronectin type III domain-containing protein 3B

Source gene: FNDC3B

Class: CBL_PTK

Location: 185:191

E3 ligase: CBL

DEGRON score: 0.9827

ASA_SCORE: 95.8143

COIL: 0.9373

CONS_SCORE: 0.4545

DSS_SCORE: 0.5759

HELIX: 0.0397

FCONS_SCORE: 0.9428

RIG_SCORE: 0.6971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I200N	TCGA-A4-A4ZT	KIRP	TCGA	DQYSKPP	CBL_PTK	0.0833
p.I200N	DO44465	KIRP	ICGC	DQYSKPP	CBL_PTK	0.0833
p.R198H	TCGA-A6-2686	COAD	TCGA	DQYSKPP	CBL_PTK	0.1389
p.R198H	DO7828	COAD	ICGC	DQYSKPP	CBL_PTK	0.1389
p.R183Q	TCGA-EO-A3AY	UCEC	TCGA	DQYSKPP	CBL_PTK	0.2778
p.R183Q	DO43202	UCEC	ICGC	DQYSKPP	CBL_PTK	0.2778
p.T179S	DO229010	COCA	ICGC	DQYSKPP	CBL_PTK	0.1667
p.T179S	DO229013	COCA	ICGC	DQYSKPP	CBL_PTK	0.1667
p.T179S	DO229003	COCA	ICGC	DQYSKPP	CBL_PTK	0.1667
p.T179S	DO229346	LAML	ICGC	DQYSKPP	CBL_PTK	0.1667
p.T179S	DO229480	LAML	ICGC	DQYSKPP	CBL_PTK	0.1667
p.T179S	DO228947	LICA	ICGC	DQYSKPP	CBL_PTK	0.1667
p.H192Q	DO48973	PBCA	ICGC	DQYSKPP	CBL_PTK	0.3056
p.S188N	SIDM00120	Prostate Carcinoma	GDSC	DQYSKPP	CBL_PTK	0.7069
p.S188N	ACH-000979	Prostate Cancer	CCLE	DQYSKPP	CBL_PTK	0.7069
p.S188N	DU-145	prostate	COSMIC	DQYSKPP	CBL_PTK	0.7069
p.P191L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DQYSKPP	CBL_PTK	0.7582
p.P191L	ACH-000918	Leukemia	CCLE	DQYSKPP	CBL_PTK	0.7582
p.P191L	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	DQYSKPP	CBL_PTK	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53EP0	Fibronectin type III domain-containing protein 3B	CBL_PTK	185:191	DQYSKPP	CBL	0.9827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons