DegronMD - Q8N2M8(CLASRP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R278W	TCGA-19-5956	GBM	TCGA	PPSY	ITCH	286:289	Mutation rewiring degron network	0.1111
p.R278W	TCGA-IB-7651	PAAD	TCGA	PPSY	ITCH	286:289	Mutation rewiring degron network	0.1111
p.R278W	DO13863	GBM	ICGC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.1111
p.R278W	DO46657	PAAD	ICGC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.1111
p.R322H	TCGA-AA-3492	COAD	TCGA	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.7133
p.R322H	TCGA-L5-A4OI	ESCA	TCGA	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.7133
p.R322H	DO8224	COAD	ICGC	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.7133
p.R322H	ACH-001369	Ovarian Cancer	CCLE	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.7133
p.R322C	TCGA-AZ-6601	COAD	TCGA	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.719
p.R322C	DO8119	COAD	ICGC	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.719
p.R83H	TCGA-CG-4306	STAD	TCGA	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.8244
p.R83H	DO38567	STAD	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.8244
p.P299L	TCGA-CM-6170	COAD	TCGA	PPSY	ITCH	286:289	Mutation rewiring degron network	0.0556
p.P299L	DO7849	COAD	ICGC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.0556
p.D78G	TCGA-CR-7379	HNSC	TCGA	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.D78G	DO14174	HNSC	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.A458T	TCGA-D1-A103	UCEC	TCGA	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.3056
p.A458T	DO229192	THCA	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.3056
p.A458T	DO42312	UCEC	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.3056
p.R292Q	TCGA-D1-A167	UCEC	TCGA	PPSY	ITCH	286:289	Mutation rewiring degron network	0.25
p.R292Q	DO40978	UCEC	ICGC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.25
p.E323K	TCGA-D5-5537	COAD	TCGA	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.7022
p.E323K	DO8922	COAD	ICGC	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.7022
p.K325E	TCGA-DD-AAD1	LIHC	TCGA	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation rewiring degron network	0.2778
p.K325E	DO52218	LIHC	ICGC	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation rewiring degron network	0.2778
p.R291H	TCGA-E6-A1LX	UCEC	TCGA	PPSY	ITCH	286:289	Mutation rewiring degron network	0.2778
p.R291H	DO41020	UCEC	ICGC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.2778
p.S447F	TCGA-EE-A2MR	SKCM	TCGA	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.2778
p.S447F	DO37819	SKCM	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.2778
p.T99I	TCGA-FI-A2F4	UCEC	TCGA	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.T99I	DO43434	UCEC	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.R440W	TCGA-JX-A3Q0	CESC	TCGA	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.0833
p.R440W	DO51607	CESC	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.0833
p.H88D	DO222717	ESCA	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.6577
p.R79Q	DO228359	LICA	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.R314L	DO229029	LICA	ICGC	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation rewiring degron network	0.2222
p.D72Y	DO229032	LICA	ICGC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.G446V	DO229037	LICA	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.25
p.S454F	DO220851	MELA	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation altering degron motif	0.7982
p.G450R	DO220906	MELA	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation altering degron motif	0.6457
p.P457T	DO51962	PRAD	ICGC	DGHRYSRSP	CBL_PTK	449:457	Mutation altering degron motif	0.7031
p.R282C	SIDM00238	Ovarian Carcinoma	GDSC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.2222
p.R282C	ACH-000947	Ovarian Cancer	CCLE	PPSY	ITCH	286:289	Mutation rewiring degron network	0.2222
p.R282C	OVK-18	ovary	COSMIC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.2222
p.G445R	SIDM01097	Other Solid Cancers	GDSC	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.2222
p.G445R	ACH-001193	Bone Cancer	CCLE	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.2222
p.P95S	SIDM00483	Esophageal Carcinoma	GDSC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1944
p.P95S	SK-GT-4	oesophagus	COSMIC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1944
p.P94H	SIDM00220	Ovarian Carcinoma	GDSC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.P94H	ACH-000962	Ovarian Cancer	CCLE	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.P94H	ACH-001145	Ovarian Cancer	CCLE	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.P94H	OC-314	ovary	COSMIC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2222
p.R312C	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation rewiring degron network	0.1667
p.R312C	ACH-001498	Lymphoma	CCLE	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation rewiring degron network	0.1667
p.R312C	Farage	haematopoietic and lymphoid tissue	COSMIC	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation rewiring degron network	0.1667
p.P465H	ACH-000780	Lung Cancer	CCLE	DGHRYSRSP	CBL_PTK	449:457	Mutation rewiring degron network	0.1111
p.S456P	ACH-000957	Colon/Colorectal Cancer	CCLE	DGHRYSRSP	CBL_PTK	449:457	Mutation altering degron motif	0.6752
p.P457L	ACH-001061	Colon/Colorectal Cancer	CCLE	DGHRYSRSP	CBL_PTK	449:457	Mutation altering degron motif	0.7582
p.R322S	ACH-001765	Sarcoma	CCLE	PTPGRE	DEG_SCF_FBW7_2	318:323	Mutation altering degron motif	0.6316
p.Y289C	ACH-002048	Sarcoma	CCLE	PPSY	ITCH	286:289	Mutation altering degron motif	0.7087
p.A280V	LIM1215	large intestine	COSMIC	PPSY	ITCH	286:289	Mutation rewiring degron network	0.1667
p.E90V	SK-UT-1	soft tissue	COSMIC	VRAHLDHIP	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7693

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLASRP

UniProt ID: Q8N2M8

Entrez ID: 11129

Protein name: CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLASRP in