DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DGHRYSRSP
Uniprot ID:
Q8N2M8
Source protein:
CLK4-associating serine/arginine rich protein
Source gene:
CLASRP
Class:
CBL_PTK
Location:
449:457
E3 ligase:
CBL
DEGRON score:
0.6565
ASA_SCORE:
104.1778
COIL:
0.8637
CONS_SCORE:
0.4768
DSS_SCORE:
0.7913
HELIX:
0.0823
FCONS_SCORE:
1.045
RIG_SCORE:
0.579
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A458T
TCGA-D1-A103
UCEC
TCGA
DGHRYSRSP
CBL_PTK
0.3056
p.A458T
DO229192
THCA
ICGC
DGHRYSRSP
CBL_PTK
0.3056
p.A458T
DO42312
UCEC
ICGC
DGHRYSRSP
CBL_PTK
0.3056
p.S447F
TCGA-EE-A2MR
SKCM
TCGA
DGHRYSRSP
CBL_PTK
0.2778
p.S447F
DO37819
SKCM
ICGC
DGHRYSRSP
CBL_PTK
0.2778
p.R440W
TCGA-JX-A3Q0
CESC
TCGA
DGHRYSRSP
CBL_PTK
0.0833
p.R440W
DO51607
CESC
ICGC
DGHRYSRSP
CBL_PTK
0.0833
p.G446V
DO229037
LICA
ICGC
DGHRYSRSP
CBL_PTK
0.25
p.S454F
DO220851
MELA
ICGC
DGHRYSRSP
CBL_PTK
0.7982
p.G450R
DO220906
MELA
ICGC
DGHRYSRSP
CBL_PTK
0.6457
p.P457T
DO51962
PRAD
ICGC
DGHRYSRSP
CBL_PTK
0.7031
p.G445R
SIDM01097
Other Solid Cancers
GDSC
DGHRYSRSP
CBL_PTK
0.2222
p.G445R
ACH-001193
Bone Cancer
CCLE
DGHRYSRSP
CBL_PTK
0.2222
p.P465H
ACH-000780
Lung Cancer
CCLE
DGHRYSRSP
CBL_PTK
0.1111
p.S456P
ACH-000957
Colon/Colorectal Cancer
CCLE
DGHRYSRSP
CBL_PTK
0.6752
p.P457L
ACH-001061
Colon/Colorectal Cancer
CCLE
DGHRYSRSP
CBL_PTK
0.7582
Drug responses associated with CLASRP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGHRYSRSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N2M8
CLK4-associating serine/arginine rich protein
CBL_PTK
449:457
DGHRYSRSP
CBL
0.6565
More...
