DegronMD

Uniprot ID: Q8N2M8

Source protein: CLK4-associating serine/arginine rich protein

Source gene: CLASRP

Class: DEG_SCF_FBW7_2

Location: 318:323

E3 ligase: FBXW7

DEGRON score: 0.9647

ASA_SCORE: 99.2333

COIL: 0.8942

CONS_SCORE: 0.4123

DSS_SCORE: 0.6372

HELIX: 0.0768

FCONS_SCORE: 0.6865

RIG_SCORE: 0.5763

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R322C	TCGA-AZ-6601	COAD	TCGA	PTPGRE	DEG_SCF_FBW7_2	0.719
p.R322C	DO8119	COAD	ICGC	PTPGRE	DEG_SCF_FBW7_2	0.719
p.R322H	TCGA-AA-3492	COAD	TCGA	PTPGRE	DEG_SCF_FBW7_2	0.7133
p.R322H	TCGA-L5-A4OI	ESCA	TCGA	PTPGRE	DEG_SCF_FBW7_2	0.7133
p.R322H	DO8224	COAD	ICGC	PTPGRE	DEG_SCF_FBW7_2	0.7133
p.R322H	ACH-001369	Ovarian Cancer	CCLE	PTPGRE	DEG_SCF_FBW7_2	0.7133
p.E323K	TCGA-D5-5537	COAD	TCGA	PTPGRE	DEG_SCF_FBW7_2	0.7022
p.E323K	DO8922	COAD	ICGC	PTPGRE	DEG_SCF_FBW7_2	0.7022
p.R322S	ACH-001765	Sarcoma	CCLE	PTPGRE	DEG_SCF_FBW7_2	0.6316
p.K325E	TCGA-DD-AAD1	LIHC	TCGA	PTPGRE	DEG_SCF_FBW7_2	0.2778
p.K325E	DO52218	LIHC	ICGC	PTPGRE	DEG_SCF_FBW7_2	0.2778
p.R314L	DO229029	LICA	ICGC	PTPGRE	DEG_SCF_FBW7_2	0.2222
p.R312C	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPGRE	DEG_SCF_FBW7_2	0.1667
p.R312C	ACH-001498	Lymphoma	CCLE	PTPGRE	DEG_SCF_FBW7_2	0.1667
p.R312C	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PTPGRE	DEG_SCF_FBW7_2	0.1667

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2M8	CLK4-associating serine/arginine rich protein	DEG_SCF_FBW7_2	318:323	PTPGRE	FBXW7	0.9647	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons